Van Dijk wants the Quadruple for Liverpool this season

first_imgLiverpool defender Virgil van Dijk revealed that he wants to win all four titles with the Reds this season, he believes Liverpool can pull it off.It’s been a very exciting last 24 hours for Liverpool and all its supporters, they just came from winning their second consecutive match in a quite complicated month filled with highly competitive matches. The first one was against Tottenham Hotspur, where the Reds beat Mauricio Pochettino’s side 2-1 and this Tuesday they defeated PSG 3-2 at Anfield Road. One of the key components of this squad is €80 million man Virgil van Dijk, the Dutch defender who is slowly becoming the Premier League’s top center-back and one of Europe’s best. If Liverpool wants to aspire to all the trophies this season, they will need him at his very best in order to accomplish such an achievement. Only one in modern English football has a treble been accomplished, it was Sir Alex Ferguson’s Manchester United back in 1999 and there is a lot of expectation surrounding Jürgen Klopp’s Liverpool because people actually think they can pull it off. When asked about the possibility, the Dutch defender didn’t deny that this is a dream all his teammates have beside him and they will do their best throughout the season to make it happen.“I want to create memories here and write history with all these boys. Everyone is excited, everyone is feeling good, everyone wants to be part of this. We know the season is very long. We have four competitions to play in and we want to win everything — that is basically our mindset. Given the size of this club and the history of this club, we want to try and win everything. It’s going to be very difficult to do but we are going to try. You need to have belief. You need to have belief in everyone in your team, and I have that belief in this team. There are players who are not even in the squad who have so much potential, so much quality, and that says a lot about our team. It’s exciting and, no, I’m never gonna get used to this. We want to compete for every competition like we did last year, and we really wanted to start well this time. You want to play these games. You want to play these clubs we are going to face. You want to play at the highest level,” said a buzzing Van Dijk right after Liverpool’s victory against PSG in the Champions League this Tuesday.Not a bad start to our @ChampionsLeague campaign. Now is time to recover and get ready for the weekend! #UCL ? pic.twitter.com/BkvhJpYbEk— Virgil van Dijk (@VirgilvDijk) September 19, 2018Cristiano Ronaldo, Nemanja Vidic, Manchester UnitedVidic: “Ronaldo is the most professional footballer I’ve seen” Andrew Smyth – September 14, 2019 Nemanja Vidic opened up on how a 21-year-old Cristiano Ronaldo’s professionalism left him stunned at Manchester United.As one of Jürgen Klopp’s biggest bets for this new season, the former Southampton defender has already proved his worth several times over this season and is arguably amongst the best players in his position throughout Europe. Just last week during the international break during the match between France and the Netherlands, Van Dijk gave us a taste of his defensive capabilities during a chance created by Kylian Mbappé himself. On the replay, you can see the Dutch player actually running faster than the PSG player in a massive sprint where the two footballers measured their abilities, this display of strength and skill dropped everybody’s jaws to the floor as nobody expected a defender to have such great reaction to a sprint from the French prodigy himself. This moment was the prelude of what was in store for everyone at Anfield Road, Van Dijk is no joke when it comes to going against the some of the top players in the world and his support during the next month will be key for Liverpool’s aspirations to come out on top before the next international break. We can’t forget that the Reds are about to embark on a highly demanding schedule that starts with a visit from Southampton, then two consecutive matches against Chelsea in two different competitions, then a visit to Napoli in the Champions League, and another visit from Manchester City.’We had a plan and we have belief’ ?? Post-#LFCPSG with @VirgilvDijk ?https://t.co/kqPA9Q0Y5n— Liverpool FC (@LFC) September 19, 2018Do you think Liverpool has what it takes to win the Quadruple this season? Please share your opinion in the comment section down below.last_img read more

Silva urges Everton to show consistency

first_imgEverton has lost the last two matches the team played in the English Premier League and for the manager, consistency is the key for victoryEverton started its 2019 the same way it ended its 2018: with a 1-0 defeat.And for manager Marco Silva, the key to return to their winning ways is consistency.“If you look at the past performances and results, we haven’t been consistent,” he told the club’s official website.“This is the moment to be honest and look clearly at the game, to analyze the match, and pass the feedback to our boys”Harry Maguire, Manchester UnitedLiverpool legend Nicol slams Harry Maguire’s Man United form Andrew Smyth – September 14, 2019 Steve Nicol believes Harry Maguire has made some “horrendous mistakes” recently, and has failed to find his best form since joining Manchester United.“I felt our team was too nervous in some moments in the match. We did not put our game out there,” he added.“We knew before the match what they [Leicester] came here to do.”“We know, because of how they respect us, how they will come here to play. They started the game with a 4-5-1, blocking the space and waiting for our mistake,” he explained.“We made a mistake and they scored in that moment, which made things more difficult for us and after that we didn’t create the good moments to change the result for us.”last_img read more

Google employees petition SF Pride to oust company from parade

first_imgOriginally published June 26. Update, June 27: Adds response from Google employees.  Share your voice Now playing: Watch this: We are honored, and humbled, by the support of all of these great activists, who have inspired us and done more for our community than we could ever hope to.And a special shout out to @CleveJones1, we are thrilled!Though @SFPride rejected our request, well keep fighting! https://t.co/7BaB49o1Ch— Ban Google From Pride (@NoPrideForGoog) June 27, 2019 6 Tags 12 Photos Google, we have some questionscenter_img Companies like Twitter, Facebook and Google have come under fire for the way they police — or don’t police– their platforms. Earlier in June, YouTube CEO Susan Wojcicki apologized for hurting the LGBTQ community with the decision not to take down the channel of a prominent user who had made homophobic remarks about a gay journalist. “If we took down that content, there would be so [much] other content we’d need to take down,” Wojcicki said. “We don’t want to be knee-jerk.”   In a statement, SF Pride said it wouldn’t remove Google from the parade.  “Google and YouTube can and must do more to elevate and protect the voices of LGBTQ+ creators on their platforms, and we’ve found that Google has been willing to listen to this criticism and is working to develop appropriate policies,” the statement said. The group also said Google has given benefits to same-sex partners and transgender employees, as well as participated in public advocacy for the LGBTQ community.  In response, the employees took to Twitter (via @NoPrideForGoog) to say although SF Pride rejected the request, they will keep fighting. They also said they’d racked up 129 signatures within 48 hours.  Comments Google employees have signed a petition about the company’s sponsorship of San Francisco Pride festivities.  Future Publishing/Getty Google employees don’t want Google sponsoring San Fransisco Pride festivities. In a letter and petition to the board of directors of San Fransisco Pride, posted to Medium on Wednesday, a group of Google employees said the company hasn’t improved its policies when it comes to the treatment of “LGBTQ+ persons, the depiction of LGBTQ+ persons, and harassment and hate speech directed at LGBTQ+ persons, on YouTube and other Google products.” As such, letting Google sponsor Pride would be painting the company in “a rainbow veneer of support,” the employees said in the letter. They asked the Pride board to revoke Google’s sponsorship of Pride 2019 and exclude it from the San Francisco Pride Parade on June 30. “Google has marched in the San Francisco Pride Parade for more than a decade and we are excited to continue the tradition this weekend. We are grateful for SF Pride’s partnership and leadership,” a Google spokesperson said in a statement. Google Nest Hub Max: A closer look at Google’s bigger smart display 3:19 Tech Industrylast_img read more

Why did Rahul Gandhi regret chowkidar chor hai jibe on Rafale verdict

first_img2019 Lok Sabha Elections: Narendra Modi vs Rahul GandhiWiki CommonsIn a massive development, Congress president Rahul Gandhi has expressed regret in the Supreme Court over his ‘Chowkidar Chor Hai’ jibe against Prime Minister Narendra Modi saying that his words got mingled in the heat of the moment and political campaigning. “My statements were used and misused by political opponents,” the Congress chief said in his statement to the Supreme Court.Terming it unfortunate, Gandhi accepted that the court never used these words. The Congress leader apologised in his reply to the top court notice in connection with a contempt plea filed against him by the Bharatiya Janata Party (BJP) leader Meenakshi Lekhi on April 12 seeking initiation of contempt proceeding against the Congress chief for attributing his remarks on the recent Rafale controversy to the top court.Earlier, the apex court had sought an explanation from Congress chief over his remark that stated: “Supreme Court said chowkidar ne chori ke hai (Supreme Court said that chowkidar is involved in a theft)”. “I want to thank the Supreme Court. The entire country is saying that Chowkidar chor hai (Chowkidar has committed theft). Supreme Court ne clear kar diya hai ki chowkidarji ne chori karwai (Supreme Court has made it clear that chowkidarji committed theft),” the Congress leader had said in Uttar Pradesh’s Amethi.The bench led by Chief Justice of India Ranjan Gogoi and Justices Deepak Gupta and Sanjeev Khanna clarified that it had not made any such observation. “We make it clear the statement attributed to this court in the address made by the respondent (Rahul Gandhi) to the media and public have been incorrectly attributed to this court,” three judges led by CJI Ranjan Gogoi said.The third phase of the Lok Sabha elections will be held on Tuesday (April 23). Voters from 12 states and two Union Territories will cast ballots across 115 constituencies —the maximum number of Lok Sabha seats going to vote — to choose from more than 1,600 candidates. Results will be declared on May 23.last_img read more

Kappas to Host Celebrity Auction and Soul Food Feast

first_imgThe Kappa Scholarship Endowment Fund of Washington, D.C. (KSEF) will host its 31st annual Celebrity Auction and Soul Food Feast on Nov. 2 at the Blackburn Center at Howard University. The silent auction runs from 2 p.m. to 3 p.m. The soul food feast begins at 3 p.m., with the liveauction immediately following the conclusion of the meal. All proceeds benefit the fund, which gives college scholarships to D.C. public schools graduates. This year’s celebrity auctioneers include, Vincent Gray, D.C. Mayor; Rosie Allen-Herring, president and CEO, United Way of the National Capital Area; Guy Lambert, WPGC-FM radio personality; and Doris E. McMillon, CEO, McMillon Communications. For more information contact Vincent Bruton at (866) 671-5295 or Michael Fauntroy at (202) 577-8048.last_img

Denver area sees more school shootings by population than nations largest metro

first_img— Tuesday’s shooting at STEM School Highlands Ranch, which ended with one student dead, eight others injured and two of their classmates in custody, prompted Coloradans to once again question whether these types of mass shootings are more prevalent here than elsewhere. Ultimately, it’s nearly impossible to be sure if a place is at a higher risk going forward, said Frank Farley, a professor of psychological studies in education at Temple University in Pennsylvania. “If you had suggested to anyone behind me or in this room that, within 20 years in 20 miles, we would have dealt with Columbine, the Aurora theater, Arapahoe High School, the shooting of Zack Parrish and four other deputies, we’d have thought you mad,” he said. “And yet here we are again.”center_img During a 6 a.m. news conference the day after Colorado’s latest school shooting, District Attorney George Brauchler made a point of declaring the tragedies that have rocked the area in recent years don’t define the “kind, compassionate, caring people” who live here. If Columbine did place the Denver area at a higher risk for future shootings, the only thing parents and schools can do is consider responses, like increasing school security and reducing access to weapons, he said. Read the whole story: The Denver Postlast_img read more

Seven BJP activists held for ransacking TMC leaders home

first_imgBalurghat: Seven BJP activists were arrested for their alleged involvement in ransacking a Trinamool leader’s house in Tarangapur, under Kaliaganj police station in North Dinajpur district.Trinamool leader Ashim Ghosh, whose residence was ransacked allegedly by the BJP activists, is the general secretary of the district.Police said the BJP workers were identified as Subrata Das, Dipak Roy, Batasu Deb Sharma, Dharani Deb Sharma, Nimai Debnath, Ramnath Mohanta and Gayanath Deb Sharma in court. All of them were remanded in jail custody.Police said the incident took place on Friday night, when the BJP activists had attacked Ghosh’s house with firearms and other weapons and ransacked it. They had also abused Ghosh and his family members.last_img

Health is wealth

first_imgA healthy body leads to a healthy mind, says a famous proverb. Health and fitness keeps our body and mind healthy and peaceful. It brings out the feeling of being well physically, mentally, spiritually and socially. Today’s sedentary lifestyle, loaded with stress and fatigue, gives less space to live a healthy and happy life. The stress and unregulated food habits make the human body much more prone to diseases such as high blood pressure, depression, hyper tension and diabetes. Also Read – ‘Playing Jojo was emotionally exhausting’Exercise is the key to a healthy and a glowing skin. Proper diet and exercise are the mainstays for a healthy lifestyle. Regular exercise helps boost your immune system and prevent some of the diseases, particularly those that involve the upper respiratory track. The fluid regulation in the body is responsible for maintaining the body fitness as water helps to flush out the toxicants from our body.Moreover, a lot of diseases can be prevented with daily exercise. Health issues such as diabetes and high blood pressure which require lifelong medication can be controlled by regular exercise which helps keep our body fit and active. People aged between 25 and 55 years are more vulnerable to diseases. People of this age group deal with a lot of stress, unpredictable schedules and unhealthy lifestyle which eventually makes them prone to health issues and diseases.  Also Read – Leslie doing new comedy special with NetflixConsidering a systematic fitness regime, they can maintain their stress levels and can lead to healthy lifestyle along with meeting all their commitments. Prioritizing people’s health and fitness, many organisations have taken a step forward to work out on the specific heath issues. Likewise FitMeIn, a fitness e-wallet lets you exercise in one go. FitMeIn believes that there are plenty of ways to boost your health and fitness level, which further encourages each person to take up exercising in their own way. It provides a passport to reach fitness studios across Delhi/NCR. FitMeIn is redefining the segment and making all fitness options accessible under one roof.Vishesh Goel, founder, FitMeIn, a CA by profession aims to build something from scratch and see it scale up. One should keep in mind that staying fit is not a destination, it is a way of life.last_img read more

Jacó Happenings

first_imgNo related posts. Congratulations to Jair Pérez, who won the 5th leg of the national surf circuit in his hometown, out-surfing Gilbert Brown, Maikol Torres and Jefferson Tascón.If Jair continues winning, he will be well on his way to becoming the national champion. Chelsea Tuach from Barbados won the Open Women’s categories over Lisbeth Vindas, Danielle Ciminero and Nataly Bernold. Jacó’s own Anthony Flores took the long-boarding division and Juan Carlos Mendoza took first place over Noe Mar McGonagle in juniors.The sixth stop on the National Tour will be held July 28-29 in Santa Teresa de Cóbano, and then it’s back to Playa Hermosa for the grand finals, slated for the weekend of August 25. For more information, visit www.surfingcr.net. Tomorrow, don’t miss the Hermosa Pro 2012 Surf Contest featuring $3,000 in prize money. It will be held out front of the Backyard in Playa Hermosa starting at 6 a.m.Under the direction of Darren Lee Cole, Teatro Jacó will hold the July Comedy Festival, Jacó Ha Ha 2012, from July 5-28. The festival will feature productions from Texas, New York City and San José. First on the schedule is Faye Lane’s Beauty Shop stories for July 5-9, followed by the Upright Citizen’s Brigade from July 12-16 and Maldito Murphy from July 20-22. Finally, Qué Zambrote will perform from July 26-28. All shows are at 8 p.m.; the first three productions will be performed in English and the last one will be in Spanish. Additionally, Upright Citizens Brigade will lead comedy workshops on July 10-11 in English, from 6-8 p.m. for $20 per session or $30 for both. Cast members of Qué Zambrote will conduct Spanish-language comedy workshops July 18-19 for $10 per session or $15 for both. For more, call 2630-9812, email info@teatrojaco.com or visit www.teatrojaco.com.The Central Pacific Women’s Group announced that its July speaker will be José Alberto Villalobos, a retired physicist who taught at the University of Costa Rica. He is passionate about astronomy and loves sharing his knowledge about calendars, especially the Maya calendar. After a brief introduction about the solar system, astronomical events and the Milky Way, he will focus on the astronomical phenomenon of 2012 and the Maya perspective. José will be at the Hotel Cocál from 9-11 a.m., Wednesday, July 18. For more information, contact centralpacificwomensgroup@gmail.com.Liana Robinson from the Jacó Library welcomes volunteer Jennifer Reinhardt from Canada. Jennifer has come down to help the library for the next five months. She’ll be planning events and fundraising for the library. If you’d like to help, email Liana at bibliotecajaco@gmail.com.If you are looking to take a new class, check out the Taller de Arte schedule. The school is offering taekwondo, belly dancing, kickboxing, zumba, tae bo, ritmix, ballet and pilates in the center of Jacó, on the second floor of the movie theater. For more information, call 8809-2679 or email tallerdearteslau@gmail.com.–Christina Truittchristina_truitt@yahoo.com  Facebook Commentslast_img read more

John Why are some of the phishing scams so blatan

first_img John: Why are some of the phishing scams so blatantly stupid? Like a Craigslist price of $2,307 for a 2013 BMW. It’s obvious to anyone. Durk: “Oh gee, I’m a Nigerian prince and I want to move $50 million to America and I’ll give you half of it if you help me.” Why are people trying a scam that’s so stupidly obvious? The answer is very simple: These are competent and professional fraudsters. If somebody falls for the Nigerian prince thing, then they’ll be stupid enough to give the fraudsters their Social Security number, their bank account number, and their password. With the Nigerian prince scam, the fraudsters get rid of the 99% of the people that aren’t that stupid right away. John: Ah. The more inane the fraud pitch is, the better the fraudsters target their market to the stupid. Doug, what’s your definition of stupidity again? Doug: Stupidity, like intelligence, comes in a number of flavors. The most common definition of stupidity is “of low intelligence” – but that’s rather circular, like saying “slow” means “not very fast.” I like to define “stupid” as the ability to see the immediate and direct consequences of actions, but the inability to see the delayed and indirect consequences. Like most criminals, black-hat hackers never see the long-term consequences – like being hunted, being held in contempt by most of society, and probably landing in jail. Or indirect consequences – like destroying their self-respect. Among other things. An even better definition of stupidity, applicable both to those who respond to the Nigerian prince scam as well as the Nigerian Prince himself, is “an unwitting tendency towards self-destruction.” Even when criminals score high on IQ tests, they still fit this definition. So while computer criminals are undoubtedly smarter than street criminals, they’re still rather stupid in very important ways. Durk: It’s relatively easy to protect yourself from being financially harmed in a hack. The first rule here is, don’t let a million different companies have your credit card number. Almost every company is perfectly willing to deal with a debit card rather than a credit card. If you keep a small amount of spending money in a debit card account, then that’s the most you can lose. And if it’s not your fault, you’re probably going to be made good. Second, you use encrypted wire transfers with your bank to make deposits. You see that little padlock up on the address line on your browser that says https rather than http? That’s an encrypted link. Just make sure that you or your browser entered your bank’s internet URL. Don’t click on an email link that appears to have come from your bank, because it may be a fraudulent phishing email that takes you to a URL with an https connection and a padlock that is NOT really your bank but sure looks exactly like your bank’s internet page and likely will have a confusingly similar URL! Recommended Link The next step is to keep your attack surface to a minimum. An attack surface is the path that you could be attacked through. For example, the more companies that have your credit or debit card numbers, the bigger your attack surface. When you buy something on the phone, tell them, “I don’t want my credit card number or debit card number being kept permanently on file. I just want to do this one transaction with you and don’t want to set up an account.” It’s in their computer and memory just long enough to clear with the bank or the credit card and then it’s gone. If the company then gets hacked, you are safer. There are only two places that have my debit card number permanently on file: PayPal and Amazon. Both of those are really serious about security. John: But the bad guys can be mighty sneaky. Durk: Yes. Clicking on an ad can load malware onto your computer if you’re not careful, especially if you use Windows. With a Mac, Gatekeeper will ask for your password, warn you that you are about to load an un-vetted program, and ask if you really want to do this. Some of those ads are little more than a pixel in size. Companies that are selling ad space on their websites don’t do anywhere near what I think is adequate to check out the advertisers. If you use Adblock Plus with Firefox, you are protected because you will never even see the ad, let alone be able to click on it.Also, you want a more secure browser than something that’s provided by Microsoft or Google. They’ve got a file on you that’s bigger than the FBI, NSA, and the CIA put together. Every time you do a search they’ve got your IP address – that is your internet protocol address which identifies you uniquely – and they also have years and years of tracking every search you’ve ever done, what you search for, and what you clicked on after you did the search. That is a vast amount of information. With that information and a bit of computer intelligence, they can figure out that your daughter is pregnant before you know it yourself. Deciphering masses of disparate data to allow for conclusions results from the availability of these dense patterns of information, in what is called the matrix effect. Microsoft and Google both make more money off of your personal information than they make off any products. The last time I looked at the contract for Windows 10 for individual users, it was 140 pages long. Buried inside there’s a section that essentially says, “All information on your computer belongs to us and we can do anything with it we want.” You agree to this by checking a box that you never read. Any time you do a Google search they’re harvesting information from you. They’ll sell it to anybody. They’ll sell it to the FSB/KGB, the DEA; they’ll sell it to the cops. If you’re getting a service for free on the internet, you need to know that you are the product. John: And they can sell this information to burglars who are local to you? Durk: Not intentionally, but yes, and these burglars then know what you drive, where you drive to and when, where your home is located. They know you’re asleep at 3 a.m., they know you have a Ferrari, they steal your Ferrari out of your driveway. John: How do you avoid this? Durk: In the case of Windows, there’s a free program you can get called ShutUp10. It reduces the amount of information getting delivered back to Microsoft from your computer. You need to keep that ShutUp10 up to date because Microsoft keeps changing the spyware they put on your computer. It’s a constant race. The web has turned into a massive theft of personal information used for marketing purposes. Also, when doing searches, go to – a ridiculous name, I know – DuckDuckGo.com. They’ll forward your search to Google and Bing and a whole bunch of other search engines, but they won’t forward your IP address, and they won’t keep a dossier on you and all your searches. Oh, incidentally, don’t use Facebook. Don’t use Twitter. They make all their money by selling your personal information. Just don’t use them. John: My son told me that travel booking sites substantially raise the available rates for flights if they see you shopping around for a specific trip. Indeed, it happened to me two days ago. I searched a fare three times during the day. The third time, the fare jumped up threefold and stayed high from then on. I thought I had missed out on a good fare. My son told me to try browsing incognito. Google Chrome has an incognito mode: turns it on. I turned it on, searched the flight again, and the price for my flight was the nice low one that it had quoted me initially. Sneaky. But I wonder if I can trust Google Chrome’s incognito mode for long. Durk: Google Chrome will still fink you out. I use Firefox, which has an incognito mode, with the extensions NoScript, Privacy Badger, Adblock Plus, Cookie Controller, and Random Agent Spoofer. Note that you do not have to restrict yourself to one browser when price shopping for expensive items. Justin’s note: Chris Wood, our tech expert and editor of Extraordinary Technology, recommended a cybersecurity stock last year that handed his readers triple-digit gains in little over a year. And he’s just found the company set to displace last year’s winner… for potential 130% profits. You can access the name of this company—and all of Chris’ latest research—with a risk-free trial subscription to Extraordinary Technology. Click here to learn more.Also be sure to check out Part 2 of Doug’s interview tomorrow, where the guys discuss other ways to start protecting yourself from hackers. Reader Mailbag Today, readers respond to our recent Dispatch on the future of electric-car maker Tesla… It’s the first time I have put pen to paper to you but I just have to say that I can’t agree more regarding your prognosis on Tesla. Believing what you have just said, back in March I placed a put, for June, on Tesla crashing, only to lose my $5,000 bet. Clearly the man [Tesla founder Elon Musk] is a perfect artist in front of the American investing public, who just follow and follow his dreams. I’m afraid that you are right, however. On the other hand, it’s great to see how you Americans can follow a dream. Is that not what makes America great? –Rodney Justin’s note: Over the next two days, I’m sharing a special interview that features Doug Casey and his colleagues on the latest crime wave that’s sweeping the globe.Below, you’ll hear from John Hunt, an MD and coauthor with Doug of Speculator and Drug Lord, and Durk Pearson, bestselling author and former rocket scientist and aerospace physicist. They recently sat down with Doug to share their best tips on how to protect yourself against the growing cyber-threat.I think you’ll find their ideas interesting and timely…John: Equifax hacks, Russian hacks, and political hacks are all competing with the Kardashians for primetime news reports. Let’s focus on something that might actually matter to each of us and that we can do something about: our own personal cybersecurity. Durk: Computer security is a lot more important than most people realize. Absent precautions, it’s like if you had a stack of $100 bills and left it on the sidewalk in front of your house. If someone happens to stroll through your neighborhood, he can just pick them up. Likewise, most people have no computer defenses at all. You have more than $100 bills in that computer. You have your future money too, and your credit. But you can become resistant to this. It’s not an impossible task. Remember the old story? You don’t have to run faster than the bear. You just have to run faster than the other guy. And that is surprisingly simple. John: So what do you advise that everyone should do now? Durk: First know that if you live in a gated residential community, you have a very low chance of being robbed. But the internet is as if everyone lives in Watts in the 1960s, or South Chicago now. John: You have to build your gates and walls. Durk: Right. Now, you don’t have to be a perfectly hard target. There is no such thing as a perfectly hard target. The CIA got hacked for a lot of their extremely dangerous hacking tools which are now out in the public domain. If the CIA can get hacked, believe me you can get hacked too. On the other hand, all you have to do is make yourself a much harder target than the value of what people can get out of you and you’re going to be left alone. They’re going to move on to somebody else who isn’t as tough. Which is most everybody. — This may spill over to SpaceX… Boring General Motors (GM) is safer. –Bruce — All Signs Point to a Giant Bull Supercycle In This Sector and the Masses Are Completely Ignoring It… Right now, the masses of “herd” investors are piling into mainstream stocks, completely convinced that this overvalued bull market will just “keep going.” But they’re ignoring an even more lucrative opportunity in a hidden sector completely outside of the equities market. Only a handful of millionaire “lone-wolf” contrarian investors are paying attention to it – licking their lips in anticipation of windfall profits that haven’t been seen in seven years. If you’re an independent thinker who is brave enough not to be just another “herd” investor, click here to learn the details of this “lone-wolf” opportunity. Recommended Link Do You Want to Profit From Today’s Marijuana Boom… But Not Sure Which Stocks to Buy? The marijuana market is on fire. Everyone wants to get rich with pot stocks today. With crazy gains of 7,820%… 17,300%… and even 69,000%, pot stocks like these averaged peak gains of 29,000%. But other pot stocks have tanked. Do you want to make money from today’s marijuana mania? Not sure which pot stocks are safe and which are risky? Then watch this presentation right now and see the 3 pot stocks to buy right now. It is interesting another guy is saying go long on Tesla and that it will be up in the high 300s by the end of Q4!–Williamlast_img read more

While Americans are busy dissecting the Michelle W

first_imgWhile Americans are busy dissecting the Michelle Wolf monologue at the White House Correspondents’ dinner, Nigerians (and experts on Nigeria) are busy expressing themselves about Monday’s meeting with President Trump and their president Muhammadu Buhari. It’s the first time Trump has met with a sub-Saharan African leader.Here’s a roundup of responses, from interviews with Nigerians and other commenters and from Twitter.Some are glad the meeting took place.”I am really excited about the recent developments, and I believe it’s a way of strengthening relationship between both countries,” says writer Divine Nwoye.Others are not fans of the U.S. President, especially in light of his reported use of a vulgar term to characterize African nations in January 2018.Desmond Okon, political commentator and resident of Lagos: “He’s a controversial human being who has a reputation for offensive comments. [Our] President should be careful with the things he says to avoid selling the country out.”Some praise Trump’s sympathy for the “killings of Christians”…Osita Obeta, who just joined he National Youth Service Scheme for the one-year mandatory stint: “I’ve always loved Trump and his frankness when it comes to talking about issues, and his stance on the senseless killings in Nigeria is a good one. Leaders should not shy away from calling a spade a spade.”… but others are skeptical.Some wonder why Trump only mentioned one group that’s suffering.And some are wondering about visas to immigrate to the U.S.There’s a call for action, not just talk.Victor Ejechi, a recent graduate of the University of Benin who lives in Lagos: Trump’s remarks needs to be acted upon before we can have a full-blown celebration. Rhetoric statements on fighting human trafficking, corruption and insecurity don’t solve problems. I hope Buhari returns to Nigeria energized to take serious actions on what he discussed with Trump.”They’re glad that corruption was mentioned but aren’t certain change is coming.Ejechi says Buhari’s war against corruption has not produced “good results”: “What have we done with all the recovered money? Has anybody been jailed for corruption?”Obeta has a different perspective: “Buhari has partly tried to eliminate corruption, but the people he is working with have not made it easy for him.”They’re glad that trade was brought up:Merit Ayibe, a journalism student: “I am happy they discussed trade because Nigeria needs to attract more investment rather than aid for real development to happen.”They have mixed feeling about U.S. aid.Ayibe: “No country can develop by depending on aid. Most of the aid we’ve collected in the past were not used well, in fact they could provide basic facilities that would address issues like malaria.”Okon: “Aid is good, but the question is what is the catch? What is the motivation behind it? If the agreement is safe after all considerations then I don’t have issues with it.”They speculate about why the meeting was held in the first place.Matthew T. Page, former State Department official and associate fellow at Chatham House: “Left to his own devices, I think President Trump would have minimal interest in meeting with President Muhammadu Buhari or any other African leader. This meeting is most likely the result of efforts by diplomats and other policymakers from both countries to bring together these two leaders to reaffirm the close — if not occasionally challenging — relationship between the United States and Africa’s largest economy and most populous country. The meeting offers presidents Buhari and Trump — both of whom are politically polarizing figures in their respective countries — the opportunity to appear engaged, statesmanlike and in control.”And everybody’s having fun with a photo of Buhari signing the White House registry:Linus Unah is a freelance journalist covering global health, conflict, agriculture, and technology in Nigeria. Find him @linusunah. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

Disabled activists say governmentfunded research

first_imgDisabled activists say government-funded research, which concludes that the programme to reassess people on incapacity benefit through the work capability assessment (WCA) was linked to 590 suicides in just three years, is both “damning” and “timely”.Campaigners, doctors and psychiatrists have been warning for several years of strong anecdotal evidence that the programme to reassess hundreds of thousands of old-style incapacity benefit (IB) claimants was causing significant harm and distress, particularly to people with mental health conditions.But now public health experts from the Universities of Liverpool and Oxford have shown in a study that, for every 10,000 IB claimants who were reassessed in England between 2010 and 2013, there were an additional six suicides, 2,700 cases of self-reported mental health problems, and an increase of more than 7,000 in the number of anti-depressants prescribed.The most significant increases took place in the most deprived local authority areas of England.Across England as a whole, the reassessment process from 2010 to 2013 was “associated with” an extra 590 suicides, 279,000 additional cases of self-reported mental health problems, and the prescribing of a further 725,000 anti-depressants.The idea for the research came originally from disabled activist Rick Burgess (pictured), who later co-founded the grassroots campaign group New Approach, and wanted “recognised and respected epidemiologists” to carry out “an academically-rigorous study” into the number of deaths caused by the WCA, with the results to be reported before the 2015 election.Together with three other leading campaigners – artist-activist Liz Crow* and New Approach co-founders Jane Bence and Nick Dilworth – Burgess began discussing the idea early last year with David Stuckler, professor of political economy and sociology at Oxford and one of the new study’s co-authors.Stuckler concluded at the time that such research was not possible because the necessary data had not been released by the government.Burgess pointed out that the research had been “started by disabled people with no funding”, but he said it was “brilliant” it had been completed, and that he felt “grimly vindicated” by evidence which would, “in any functioning democracy”, cause a government to be removed by a vote of no confidence.He said: “It does show welfare reform is causing excess deaths, which is what we have always said, and it has been reported in most media, so the idea to have a rigorous, reputable study done was worth it for campaigners, even though it is not exhaustive and there is much data still to be wrestled out of the hands of this very secretive government.”Linda Burnip, co-founder of Disabled People Against Cuts (DPAC), said: “This research simply confirms what we’ve all known for a long time, but is very timely both in relation to the ongoing UN inquiry into the grave and systematic violation of disabled people’s human rights and to DPAC’s campaigning priorities for 2016.“The main focus of this campaigning will be an end to people being wrongly pushed to their deaths by the current benefit system inflicted on them by [work and pensions secretary] Iain Duncan Smith.”Mark Harrison, chief executive of Equal Lives, said the research was “very timely and damning of a brutal system which is damaging people’s mental health”. He said it was clear the government was intent on cutting public spending and dismantling public services “whatever the human consequences”. He said: “To them, people who commit suicide or whose mental health conditions deteriorate as a result of their policies are merely collateral damage in their austerity war. “I am sure the government will ignore the evidence in this report as it does with all the facts and statistics which show their policies are damaging the life chances and killing poor and disabled people.”He added: “This poses a real challenge for the leaders of the disability rights movement and disabled people’s organisations in how to respond to politicians and civil servants who are not listening and aren’t interested in disabled people’s lives and human rights.”John McArdle, co-founder of Black Triangle, said: “This is yet another damning body of evidence that makes it clear that the UK government is guilty of implementing policies and systems that are leading directly to the deaths of hundreds, if not thousands, of chronically ill and/or disabled people.“It remains the case that there exists no safety protocol built into the DWP-Maximus [the US company which carries out the tests] disability assessment regime.“Vital medical evidence is neither sought by, nor provided to, the DWP and we are firmly of the view that this is a deliberate policy.“The Westminster government knows fine well that were such vital evidence to be provided, far fewer people would be found fit for work and so the Tories’ overarching goal of destroying our social security safety net as part of George Osborne’s ‘long-term economic plan’ would fail to meet its target.“Lives lost are accepted as being collateral damage in achieving this aim. These deaths have irrefutably arisen as a direct consequence of the implementation of an official policy that is ‘intentionally or knowingly reckless with a depraved disregard for life’.“The Westminster government is therefore unquestionably guilty of democide.”Michelle Maher, of the WOWcampaign and petition, said the research “joins a long list of evidence given to the government on the horrific impact of medical assessments”.She said: “I am still concerned that the government will claim they are listening and change the WCA, making it worse, under the heading of helping sick and disabled people into work because work is good for us.“The numerous reports into foodbanks have been ignored or justified in appalling ways, with Tory members celebrating their existence.“I fear the same will be said of the WCA and reports of the language the DWP and Iain Duncan Smith are using would indicate a direction of change that will be far worse.”The study’s authors say their findings also demonstrate the need for a cumulative assessment of the impact of austerity measures on disabled people, as demanded by the WOWcampaign.The study was published online in the Journal of Epidemiology and Community Health, and carried out by researchers from the University of Liverpool’s Institute of Psychology, Health and Society, and from the University of Oxford, and funded by the National Institute for Health Research, which itself is funded by the Department of Health.Ben Barr, the study’s lead author and senior clinical lecturer in applied public health research at the University of Liverpool, said: “The programme of reassessing people on disability benefits using the WCA was independently associated with an increase in suicides, self-reported mental health problems and antidepressant prescribing.“This policy may have had serious adverse consequences for mental health in England, which could outweigh any benefits that arise from moving people off disability benefits.”But DWP dismissed the report’s findings.A DWP spokesman said: “This report is wholly misleading, and the authors themselves caution that no conclusions can be drawn about cause and effect.“In addition, it is concerning that they provide no evidence that the people with mental health problems highlighted in the report even underwent a work capability assessment.”He pointed to the five independent reviews of the WCA – the first three carried out by Professor Malcolm Harrington – and “significant improvements to the process” made by DWP since 2010, including to how the WCA is used to assess people with mental health conditions.He also said the percentage of people with mental health conditions who receive the highest level of support after being assessed for eligibility for employment and support allowance through the WCA has “more than tripled since 2010”.Barr said DWP’s response was “disappointing”, and that none of the other factors researchers had looked at as possible causes, such as cuts to local government services or a fall in wages, could explain the rise in suicides and the deterioration in mental health.And he said the increases only happened among age groups most affected by the WCA, while the rise in mental health problems “tended to occur shortly after the increase in people undergoing the WCA in each area”.Barr also called on DWP to publish any data it has on claimants’ mental health before, during and after the assessment.He said: “Unfortunately, the DWP implemented the policy without a controlled trial or any plans to evaluate its impact on mental health. “Given that data is not currently available on the specific individuals who underwent the WCA and there is no trial evidence, the next best approach to investigate the potential effects on mental health is the one we applied in our study, using appropriate statistical methods to control for alternative explanations for these trends.  “Our findings should at the very least raise serious concerns for the DWP that the potential negative impacts of the WCA need to be investigated further.” Sue Bott, deputy chief executive of Disability Rights UK, added: “It is shameful for the DWP to dismiss in such an offhand manner a serious academic study showing a worrying rise in suicides and mental health issues connected to the WCA. “This evidence, added to the growing weight of evidence from tribunals and concerns from coroners, should surely lead to a complete rethink on the WCA, which by any measure is not fit for purpose.”*Crow’s own piece of work, We Are Figures, grew out of the discussions with Stuckler, but because of the difficulty of identifying how many austerity-related deaths there had been, she focused on the human cost of austeritylast_img read more

iPad Pro Gets a Bigger Screen But Comes at a High Price

first_img –shares Image credit: Apple Apple’s smallest iPad Pro is getting bigger.Speaking at WWDC on Monday, Apple CEO Tim Cook called the new 10.5-inch version the “perfect size” for the company’s flagship tablet. It replaces the 9.7-inch version, although Apple is keeping the 12.9-inch model, which it also refreshed at WWDC. Despite the larger screen, the 10.5-inch iPad Pro didn’t get any heavier than its predecessor — it still weighs about one pound. Inside, it’s powered by an A10X Fusion chip and includes the same cameras as the iPhone 7, which means a 12-megapixel main camera with optical image stabilization, along with a 7-megapixel front shooter. And since one of the iPad Pro’s chief advantages over the regular iPad is compatibility with the Apple Pencil, there’s also a redesigned Retina display that achieves smoother scrolling and drawing with the pencil thanks to 20-millisecond latency.If you’re editing video footage with your iPad Pro, the expanded screen real estate, better Pencil reaction times and A10X chip will likely make for a smoother experience. And if you’re editing video outside or in other challenging light conditions, you’ll appreciate that the display can automatically adjust its white balance to compensate. While that feature is also available in the previous generation, it’s another reason to chose the iPad Pro over the iPad.The main reason not to spring for the iPad Pro is, of course, its astronomical price, and that’s no less true with Monday’s update. If you’re a current 9.7-inch iPad Pro owner, you’ll need to replace your keyboard if you upgrade to the 10.5-inch model. Apple is offering a new $159 full-size Smart Keyboard that also doubles as a cover to fit the 10.5-inch iPad Pro.Add the keyboard and pencil ($99) to the $649 asking price for the 64GB Wi-Fi-only 10.5-inch iPad Pro, and you start to enter ultrabook territory, which means that even with a larger size, the base-model iPad Pro will have limited appeal among cost-conscious professionals. The refreshed 12.9-inch model, which gets the same internal improvements as its little cousin, starts at $799 for a 64GB Wi-Fi-only version. Both models can be ordered starting Monday with a cellular antenna for an additional $130. iOS 11 will bring additional capabilities to the iPad Pro when it rolls out this fall, including new multi-tasking features like drag and drop and an easier-to-use app picker menu. Apple Register Now » Add to Queue News reporter Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goalscenter_img Next Article This story originally appeared on PCMag iPad Pro Gets a Bigger Screen, But Comes at a High Price Tom Brant Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. This fall, iOS 11 will also bring additional multi-tasking capabilities, like drag and drop.last_img read more

Should You Launch an ICO to Raise Money for Your Startup

first_img Guest Writer Learn how to successfully navigate family business dynamics and build businesses that excel. In the past few months, you’ve likely heard about initial coin offering (ICO) fundraising, as some startups have experienced a significant amount of funding this way. Could ICOs replace traditional venture capital?On the surface, ICOs appear to be the new, successful startup journey alternative. However, before making any hasty decisions, it is imperative that you understand how these two very different types of funding compare.Related: Basic Blockchain Lingo Every Entrepreneur Needs to KnowICOs have seen immense growth, but there are challenges.There’s been a significant amount of media coverage in relation to ICOs, especially as the blockchain and cryptocurrency industry evolves. However, taking a closer look, it appears that there are some critical gaps in the available information, which for many is misleading.Of course, there are advantages to this model, including more rapid funding and fewer regulations — which may actually be a double-edged sword. Unlike the traditional model, which requires startups to first build a company, generate revenue, and then get funding from angel investors (before landing a venture capitalist), ICOs provide somewhat of a shortcut.The growth of ICOs alone is enough to turn heads. In June of this year, ICOs surpassed $550 million in funding, which was more than what was raised through venture capital fundraising. However, these benefits are not enough to convince many partners and investors.Being an open, unregulated system, anything can happen, and when you’re dealing with millions of dollars, “anything” isn’t exactly what you want to hear. In fact, one of the primary concerns for investors is the ambiguity of utility tokens, resulting in varying rights. There are also a number of significant risks involved, including taxable proceeds.Related: 3 Things You Need to Know Before Starting Your Own ICOICOs simply are not ready to take over traditional venture capital. Here’s why.Although many support ICOs and blockchain technology overall, it is the general consensus that the technology itself is still immature, leading to many risk factors. In some countries, such as China, ICOs have been banned due to a lack of regulation, as well as a high rate of fraudulent and illegal activity.If you are considering the ICO market to fund your startup, please consider the following in relation to traditional venture capital.Poor liquidity. Although companies are raising real capital, without enough liquidity, the participation from buyers quickly outweighs the supports of market buyers. Strict regulations and the use of multiple currencies also contribute to poor liquidity.Quality control and increased risk of scams. One review, published by The Wall Street Journal, found that after analyzing 1,450 ICOs, 20 percent contained major red flags. This included plagiarized documents, fake executive teams and guaranteed returns.Higher failure rate. As of February 2018, 46 percent of the previous year’s ICOs had already failed — despite the fact that they had raised more than $104 million. This is resulting in what’s referred to as a “digital graveyard,” as many of these ICOs appear to have been doomed from the start.At the end of the day, the majority of ICO-funded startups are poorly managed and lack the required cash flow. Since the cash raised by an ICO doesn’t technically have any legal leverage, as they are not currently regulated, this option is risky for investors, as well as your reputation.Related: Want to Invest in an ICO in 2018? Here’s All You Need to Know.Token sales and the phenomenon surrounding ICOs certainly has potential, but it’s still in its infancy. It’s the new “Wild West,” and until some of the major kinks are worked out, venture capital is still largely the most promising route, as you will attract loyal investors while building valuable connections.Regardless, this is an industry that should be watched closely, as many industry leaders, including Bill Gates and John Donahoe, support the evolution of digital currency. Based on your current business model and business plan, are you unsure which option is best? 4 min read July 18, 2018 Register Now » Image credit: Peshkova | Getty Images Rahul Varshneya Add to Queue As of February 2018, 46 percent of the previous year’s ICOs had already failed — despite the fact that they had raised more than $104 million. –shares Opinions expressed by Entrepreneur contributors are their own. Next Article Should You Launch an ICO to Raise Money for Your Startup? Free Webinar | July 31: Secrets to Running a Successful Family Business Technology Co-founder at Arkenealast_img read more

Bill Gates Says These Tech Innovations Will Change the World

first_img Register Now » February 28, 2019 The billionaire philanthropist weighed in on the scientific advances that he believes will make an impact in 2019 and beyond Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Bill Gates has made his fortune, and has given much of it away, thinking about the endeavors that will make our the world a healthier, connected and equitable place. Recently, the MIT Technology Review asked the Gates Foundation and Microsoft co-founder to share the inventions and technologies that he believes will effect real change this year and beyond.Some of the advances he offered up include projects such as Dactyl, which teaches robots how to develop fine motor skills like flipping a block in its hand, and work being done to develop machines that could pull carbon dioxide from the air to lessen the effects of climate change.Given his interest in improving conditions around the world, it’s unsurprising that most of the innovations on Gates’s list focus on wellness.Related: Bill Gates Made These 15 Predictions Back in 1999 — and It’s Scary How Accurate He WasSome of these include green toilets that can get rid of waste and treat water at the same time, plant-based meat alternatives that are developed in the lab, customized cancer vaccines tailored to an individual patient’s needs and a capsule with a mini microscope attached to it that would allow physicians to check kids and infants for gut issues without having to use anesthesia.Looking even further ahead to the future, Gates shared what we wanted to see on his potential list 20 years from now.“I would hope to see technologies that center almost entirely on well-being. I think the brilliant minds of the future will focus on more metaphysical questions: How do we make people happier? How do we create meaningful connections? How do we help everyone live a fulfilling life?” Gates wrote. “I would love to see these questions shape the 2039 list, because it would mean that we’ve successfully fought back disease (and dealt with climate change). I can’t imagine a greater sign of progress than that.” Bill Gates Says These Tech Innovations Will Change the World Bill Gates –shares Next Article center_img Staff Writer. Covers leadership, media, technology and culture. 2 min read Image credit: Thierry Monasse | Getty Images Nina Zipkin Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Add to Queue Entrepreneur Stafflast_img read more

Updates Make Uber More Accessible to the Deaf Start Up Your Day

first_imgStart Up Your Day April 20, 2016 Image credit: Shutterstock | Enhanced by Entrepreneur –shares 2019 Entrepreneur 360 List Entrepreneur Staff Add to Queue Entrepreneur Staffcenter_img 1 min read Updates Make Uber More Accessible to the Deaf – Start Up Your Day Roundup Next Article Looking for the latest headlines in small business, innovation and tech? Our Start Up Your Day recaps are posted every morning to keep you current. Accessible. And update makes Uber more accessible to deaf drivers and passengers.  Super users. Facebook might start paying some users, says Fortune. Slipping. Yahoo’s sale can’t come quickly enough. This past quarter it posted a double digit loss. One of a kind. Each city has it’s own microbe signature, according to a new study.   About the other night. Customer whose midnight McDonald’s story went viral has a confession: He made it up. Good bit in the eighties. The Commodore 64 is having a comeback — with some important updates.  The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apply Now »last_img read more

Iteris Announces Closing of Acquisition of Albeck Gerken

first_img AcquisitionAlbeck Gerkenintelligent transportation systemsIterisMarketing TechnologyNews Previous ArticleNIMBL, Techedge Group and Openbravo Sign a Strategic Collaboration Agreement for the Retail SectorNext ArticleMerkle Releases Customer Experience Impact Report Iteris Announces Closing of Acquisition of Albeck Gerken Business WireJuly 5, 2019, 3:22 pmJuly 5, 2019 Iteris, Inc., the global leader in applied informatics for transportation and agriculture, announced the completion of its previously announced acquisition of Albeck Gerken, Inc., a privately held traffic operations engineering services provider headquartered in Tampa, Florida, with offices in Orlando (FL), Virginia Beach (VA) and Chadds Ford (PA).“Albeck Gerken’s extensive traffic engineering and consulting experience will continue to improve the lives of Florida citizens and travelers, as well as road users in the Midwest and Mid-Atlantic, through enhanced arterial traffic operations and safety.”Albeck Gerken will operate as a wholly owned subsidiary of Iteris, with the former Albeck Gerken employees being aligned with Iteris’ Transportation Systems business segment.“We are excited to complete this transaction and move forward with the process of integrating Albeck Gerken into the Iteris family,” said Ramin Massoumi, senior vice president and general manager, Transportation Systems at Iteris. “Albeck Gerken’s highly respected team of traffic operations engineering and consulting experts will join an equally respected team of experts in planning, signal operation, and intelligent transportation systems (ITS) design, integration and data analytics. The combined teams will provide unparalleled capabilities to improve safety and mobility for road users in Florida, the Midwest and Mid-Atlantic.”Marketing Technology News: Taptica International Rebrand Reflects Video Advertising Leadership“I am thrilled to announce the completion of Albeck Gerken’s acquisition by Iteris and the start of our employees’ integration into the Iteris family,” said Jeff Gerken, president of Albeck Gerken. “Albeck Gerken’s extensive traffic engineering and consulting experience will continue to improve the lives of Florida citizens and travelers, as well as road users in the Midwest and Mid-Atlantic, through enhanced arterial traffic operations and safety.”Marketing Technology News: SEMI Teams with Cornell University to Accelerate Technology Development Using Machine Learning and AIThe acquisition closed for a total purchase price of $10.7 million in cash and stock, with the ability for key principals to realize an additional $2.3 million in other incentives over three years from the date of close. For the fiscal year ending December 31, 2018, Albeck Gerken’s audited GAAP revenue was $8.1 million and EBITDA was $2.0 million.Marketing Technology News: LivePerson Wins 2019 Artificial Intelligence Breakthrough Awardlast_img read more

Researchers succeed in humanization of mouse antibodies targeting human herpesvirus 6B

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Apr 26 2019A research group led by Professor Yasuko Mori (Division of Clinical Virology, Center for Infectious Diseases, Kobe University) have succeeded in humanization of mouse antibodies that can neutralize the infection caused by human herpesvirus 6B (HHV-6B). Infection by HHV-6B in infants can lead to complications such as encephalitis (brain inflammation) but an effective way to control the infection has not yet been found.Professor Mori’s research team created “humanized” antibodies based on the mouse (murine) antibodies for HHV-6B. The findings were published on March 6 in the online edition of theJournal of Virology, and have also been introduced in the HHV-6 Foundation Newsletter.Almost every child between the ages of six and eighteen months will become infected with HHV-6B. The initial infection causes sudden-onset fever and rash. The condition has a favorable prognosis, but roughly 150 cases a year result in encephalitis and around half of these patients are left with neurological complications. HHV-6B remains latent in our bodies after initial infection, and can reactivate when our immune system defenses are low. This can be particularly bad for patients who have received stem cell transplants, who can experience frequent and life-threatening encephalitis after transplantation.Professor Mori’s team had already identified the protein complex gH/gL/gQ1/gQ2 as an essential factor for HHV-6B infection, and the human cellular receptor CD134 (OX40) that expresses on stimulated T-cells, the targets of infection. They showed in previous studies that the interaction between this protein complex and receptor is the key to infection (Figure 1). By creating monoclonal antibodies from mice, they showed that antibodies which block the activity of the gH/gL/gQ1/gQ2 complex can be used to regulate the HHV-6B infection (figure 1). The team’s next goal is to develop clinically applicable treatment that can tackle the HHV-6B gH/gL/gQ1/gQ2 complex.Related StoriesTreating women with thyroid antibodies with Levothyroxine do not increase live birth ratePremature babies also have protective anti-viral antibodiesScientists discover rare autoimmune disease triggered by testicular cancerHowever, antibodies from mice are targeted by the human immune system and destroyed when they enter our bodies, so further alterations are necessary to suppress the immune reaction in our bodies before this can be used in clinical settings. Using gene-altering technology, the team tested the humanization of mouse antibodies: they created a chimeric antibody by replacing the mouse antibodies with human antibodies in the constant domain, only leaving the parts in the variable domain that directly act against HHV-6B.In this study the team altered two types of mouse IgG antibodies to target gH and gQ1 in the HHV-6B gH/gL/gQ1/gQ2 complex. First they analyzed the DNA sequence of the mouse antibodies, and made a chimeric human-mouse gene (figure 2). They purified the chimeric antibodies produced by introducing this gene to cell cultures, and confirmed that the antibodies had maintained their effectiveness against the HHV-6B gH/gL/gQ1/gQ2 complex. By carrying out further quantitative analysis they verified that the chimera antibodies were able to block the infection of HHV-6B with the same effectiveness as mouse antibodies.This research successfully created artificial antibodies which are both effective against HHV-6B and trigger a lower response from the human immune system. These antibodies still contain parts that originate from mice, so the next step is to replace these parts with human antibodies to create antibodies that are suitable for clinical use. HHV-6B only infects humans, meaning there is no animal model for infection, and it is hard to evaluate the effectiveness of these antibodies within a living organism. In the future if animal models can be available to test this, we hope that the results can help to create antibody-based treatments for HHV-6B infection. Source:http://www.kobe-u.ac.jp/research_at_kobe_en/NEWS/news/2019_04_26_01.htmllast_img read more

Amazon tries to prove its not a Dickensian workhouse opinion

first_img Tech News 04 Jul 2019 Amazon exec fires back at John Oliver after HBO segment on warehouses: ‘He is wrong’ Related News It’s clear from Amazon’s public relations efforts that it is sensitive about the perception that the company’s warehouses – where a material portion of Amazon’s more than 630,000 full- and part-time employees work – are Dickensian sweatshops that trap people in low-wage jobs until they can be replaced by robots. — AFP World 27 Jun 2019 Bernie Sanders seeks U.S. voters on live-streaming gaming site Related News You can identify companies’ sore spots by what gets them angry.   Last week, the executive in charge of Amazon.com Inc’s logistics operation tweeted a rebuttal to a television show. Comedian John Oliver had devoted one of his trademark scathing and hilarious HBO segments to the working conditions in warehouses that handle e-commerce orders. Amazon was not the only company pilloried, but it was the most prominent.   “I am proud of our team and to suggest they would work in an environment like the one portrayed is insulting,” Dave Clark, senior vice-president of operations for Amazon, tweeted to Oliver’s TV series.  Clark last year also punched back against criticisms from Bernie Sanders, the US senator and presidential candidate, who had repeatedly taken Amazon to task for what he said were low wages and poor treatment of warehouse workers. Soon afterward, Amazon essentially capitulated to Sanders by announcing it would increase the minimum wage for its US workers to US$15 (RM62) an hour.   Tech News 10 Jul 2019 Amazon workers in Minnesota plan six-hour strike during Prime Day event Nothing happens by accident, not even tweets. It’s clear from Amazon’s public relations efforts that it is sensitive about the perception that the company’s warehouses – where a material portion of Amazon’s more than 630,000 full- and part-time employees work – are Dickensian sweatshops that trap people in low-wage jobs until they can be replaced by robots.  This perception is not new, but there’s a sharper edge now to Amazon’s refutations of these claims. Amazon also seems anxious at the mere idea floated by outsiders that its cashier-less technology for retail stores might spread beyond its experimental Go convenience stores.   That is important context for Amazon’s announcement on Thursday that it plans to spend more than US$700mil (RM2.87bil) over the next few years to train its US employees to move into more highly skilled jobs inside or outside of Amazon.  The company already offers employee-advancement programmes such as college tuition reimbursement, as do many other businesses. Amazon’s newly disclosed training initiatives aren’t limited to warehouse workers and have multiple elements. Non-technical Amazon workers can learn software engineering or information-technology support skills, technical ones can receive on-site training in more advanced software, and Amazon pledged to expand its existing training certification programme for warehouse workers to get qualified for in-demand fields such as nursing.  Of course, it remains to be seen how useful these new or expanding training programmes will be, but it’s both a good thing to do and a pragmatic step. As the labour market tightens in the US, it’s sensible for companies to sweeten pay, benefits and perks to attract new employees and keep them from leaving. (Full disclosure: One of my family members works for a labour union that advocates for higher wages and other employee benefits.)  It’s also useful for tackling that sweatshop perception, which gets more attention as Amazon’s heft and profile grow. The company’s stock market value is hovering again near that symbolic US$1tril (RM4.11tril) level. Jeff Bezos, Amazon’s founder and chief executive officer, is the wealthiest person in the world thanks largely to his holdings of Amazon stock.  And Amazon is unique among US technology superpowers in its reliance on a large number of blue-collar workers. The median annual total compensation for Amazon’s full-time US workers last year was nearly US$35,100 (RM144,348), which reflected two months of the minimum wage increase. The median wage of one of the company’s peers, Google parent company Alphabet Inc, was about US$247,000 (RM1.01mil).(1)  There are other things Amazon gets mad about now. Amazon is punchy at claims from some politicians that it doesn’t pay its fair share in taxes, or that it’s a muscular corporate giant swallowing America’s retail industry. It’s not clear that Amazon has changed how it behaves in reaction to those types of criticisms. But when it comes to the perception of Amazon as a sweatshop, the company’s rebuttals are more than just words.   (1) The Alphabet and Amazon figures are not comparable. Amazon singled out a pay figure for full-time US workers, for example, while Alphabet’s pay number is global. Amazon says the annualised median total compensation of all its employees was less than US$29,000 (RM119,262) last year. – Bloomberg(Shira Ovide is a Bloomberg Opinion columnist covering technology. She previously was a reporter for the Wall Street Journal.) {{category}} {{time}} {{title}}last_img read more