Wawrinka in Geneva final as Nishikori slumps

first_imgStanislas “Stan” Wawrinka, of Switzerland, returns a ball to Andrey Kuznetsov of Russia, during their semifinal match at the Geneva Open tennis tournament in Geneva, Switzerland, Friday, May 26, 2017. (Salvatore Di Nolfi/Keystone via AP)Top seed and defending champion Stan Wawrinka reached the Geneva claycourt final on Friday where he’ll face German outsider Mischa Zverev who stunned Japan’s Kei Nishikori 6-4, 3-6, 6-3.Wawrinka, 32, eased into the final by seeing off Russian world number 85 Andrey Kuznetsov 6-3, 7-6 (7/4).ADVERTISEMENT Cayetano dares Lacson, Drilon to take lie-detector test: Wala akong kinita sa SEA Games Sports Related Videospowered by AdSparcRead Next MOST READ Nishikori, fighting for fitness and form after a wrist injury forced him out of the Rome Masters last week, looked jaded against Zverev having needed to save three match points in the previous round against Kevin Anderson.Qualifier Zverev, the older brother of Alexander Zverev who stunned Novak Djokovic in the Rome Masters final, who will attempt to capture his maiden tour title in what will be his first final appearance in seven years.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSMalditas save PH from shutoutSPORTSPrivate companies step in to help SEA Games hostingWawrinka is seeking his first title of the year in what would be a major boost ahead of the French Open which starts on Sunday. Pagasa: Storm intensifies as it nears PAR Injury-plagued Del Potro confirms for French Open Palace: Duterte to hear out security execs on alleged China control of NGCP Lacson: SEA Games fund put in foundation like ‘Napoles case’ Panelo suggests discounted SEA Games tickets for students PLAY LIST 01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes Don’t miss out on the latest news and information. BREAKING: Cop killed, 11 hurt in Misamis Oriental grenade blast BREAKING: Cop killed, 11 hurt in Misamis Oriental grenade blast LATEST STORIES BSP survey: PH banks see bright horizon amid dark global recession clouds View comments Every 18 seconds someone is diagnosed with HIVlast_img read more

PH bows out of 3×3 U-18 quarters

first_imgEncho Serrano tries to score past the stingy Belgian defense. Photo by Fiba.comThe Philippines staged a gallant stand but fell to Belgium, 18-14, Sunday in the quarterfinals of the 2017 Fiba 3×3 Under-18 World Cup in Chengdu, China.The young Nationals could not sustain their hot start as they lost hold of a 7-4 lead and allowed the Belgians to stage a 6-1 run and grab the 10-8 advantage.ADVERTISEMENT View comments Though Encho Serrano and AJ Edu brought the Philippines back and tied the game at 12, Vincent Peeters anchored Belgium’s strong finishing kick to earn a spot in the semifinals and face Slovenia.The Philippines could still hold its head high as the boys towed the country to its best ever finish in the tournament since its foundation in 2012.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsSerrano topped the Philippines with six points, while Edu added five markers. Juan Gomez de Liano had three in the game. /atmThe Scores: What ‘missteps’? China furious as Trump signs bills in support of Hong Kong Cayetano to unmask people behind ‘smear campaign’ vs him, SEA Games Pagasa: Kammuri now a typhoon, may enter PAR by weekend MOST READ Another vape smoker nabbed in Lucena Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ BELGIUM 18 – Peeters 6, Nouhi 5, Fogang 5, Coppens 2.PHILIPPINES 14 – Serrano 6, Edu 5, Gomez de Liano 3, Amsali 0.Sports Related Videospowered by AdSparcRead Next Lacson: SEA Games fund put in foundation like ‘Napoles case’ LOOK: Jane De Leon meets fellow ‘Darna’ Marian Rivera Don’t miss out on the latest news and information. From former school teacher to world champion, Horn fulfills dream LATEST STORIES Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Gameslast_img read more

HMMs CEO Seeks to Strengthen Ties with 2M Alliance

first_imgzoomSource: Flickr – under the CC BY 2.0 license; Image by: Kees Torn The new CEO of South Korean shipping company Hyundai Merchant Marine (HMM) revealed plans to “consolidate the relationship” with 2M carriers, Maersk Line and Mediterranean Shipping Company (MSC). Jae-hoon Bae, who was appointed as HMM’s President and CEO last month, will be visiting Denmark and Switzerland, the countries where the 2M partners are headquartered, this week.The purpose of the CEO’s visit is reportedly the extension of a strategic deal with 2M. Bae wants South Korean shipping company to become a full 2M member next year, the Wall Street Journal cited a person with knowledge of HMM’s efforts as saying.Back in 2017, HMM signed the agreement with Maersk and MSC, launching the parties’ strategic cooperation on East-West trades. The three-year strategic cooperation is set to expire in April 2020 but has an extension option.The deal includes a series of slot exchanges and slot purchases on the abovementioned route, as well as 2M taking over a number of charters and operations of vessels currently chartered to HMM.Last year, industry analysts expressed their concerns that HMM would part its ways with 2M once the deal expires. The strategic cooperation was described as disadvantageous to HMM as the South Korean company is not a full member of the alliance.What is more, HMM is not the only 2M Alliance strategic partner. In July last year, Maersk and MSC inked a strategic agreement with shipping company ZIM, deciding to swap slots on five loops on the Asia-US East Coast trade. The carriers expanded their cooperation in January 2019 as they agreed to share slots on select 2M services also on the Asia-US West Coast and Asia-Mediterranean trade lanes.In December 2018, HMM was still not sure what course its relationship with 2M would take. The company, however, told World Maritime News that it maintained good ties with the alliance partners.During his European tour this week, HMM’s CEO will be also visiting the European headquarter of HMM, located in London. Furthermore, Bae will meet Kitack Lim, the Secretary-General of the International Maritime Organization (IMO), to share opinions and views on the IMO 2020 environmental regulation and upcoming regulatory measure on CO2 emissions.last_img read more

Commentary A gift wrapped pass to the NFL for Terrelle Pryor

Ohio State has gift wrapped Terrelle Pryor’s going-away present in the form of a punishment. In the last couple of days Pryor’s journey to the NFL has hit a couple of speed bumps, with his eligibility to a supplemental draft coming into question. The letter of the rule states that a player may only enter a supplemental draft if their situation changes and they are not able to participate in the next season. Technically, between the deadline to declare for the draft in January and when Pryor left the university on June 8, his situation had not changed. Technically. When the draft deadline came, Pryor was suspended for the first five games of the 2011 season. At that time the “tat-5” scandal seemed to be under control. Everything was (relatively) normal. The Buckeyes had won the Sugar Bowl The Sugar Bowl was sucked into the black hole of the sporting world. And compliance problems with head coach Jim Tressel were non-existent. Pryor had a contract with the coach to remain on the Buckeye squad for the 2011 season in exchange to play in the Sugar Bowl for nothing. While inevitably Pryor still had his doubts about the season, he still had Tressel to fall back on. One thing that is clearly evident from the transcript of Tressel’s interview from the NCAA, it’s that Pryor and Tressel were very close. Pryor depended on the coach for more than just football related issues. When all hell broke loose on March 8, Tressel received a two-game suspension from the university. A suspension that a short time later was increased to a five-game suspension. After more and more of the scandal developed, it became clear that the season was not going to be what everyone had thought it was going to be. Then on May 30, Tressel resigned (read: retired) from the university. I think it’s safe to say Pryor’s situation had changed. Seemingly following Tressel step for step, Pryor was gone a week later to pursue an NFL career. He had planned to enter a supplemental draft. The rules for a supplemental draft changed after Cleveland Browns quarterback Bernie Kosar used the supplemental draft to avoid being drafted by the Minnesota Vikings. He was drafted by Cleveland in the supplemental, and since then, the rules for supplemental draft eligibility have tightened. The rule lists three reasons to let someone enter a supplemental draft: flunking out of school, graduating and deciding to leave and being kicked off the team. As of earlier today, Pryor did not meet any of these requirements, technically. Cleverly disguised as a punishment, the university did the best thing for Pryor to help him pursue his NFL dream. They sent him a letter on Tuesday banning him from all athletic facilities for five years, and declared him ineligible from intercollegiate play. The letter states that this decision was made due to his decision not to talk to NCAA investigators. “The University must declare you ineligible for intercollegiate competition,” the letter continued. “Due to your failure to cooperate, the University must also disassociate you from its athletic program for a period of five (5) years.” Sure, he won’t be able to come back to Columbus to workout at OSU’s gym in the off-season. But let’s be honest, why would Pryor ever come back to Columbus? Whether they will admit it or not, the university might as well have put a bow on that letter to Pryor, as that should be the last step for Pryor to get into the NFL. Thanks to OSU, expect Pryor to be eligible for a supplemental draft (whenever that may be). read more

iPad Pro Gets a Bigger Screen But Comes at a High Price

first_img –shares Image credit: Apple Apple’s smallest iPad Pro is getting bigger.Speaking at WWDC on Monday, Apple CEO Tim Cook called the new 10.5-inch version the “perfect size” for the company’s flagship tablet. It replaces the 9.7-inch version, although Apple is keeping the 12.9-inch model, which it also refreshed at WWDC. Despite the larger screen, the 10.5-inch iPad Pro didn’t get any heavier than its predecessor — it still weighs about one pound. Inside, it’s powered by an A10X Fusion chip and includes the same cameras as the iPhone 7, which means a 12-megapixel main camera with optical image stabilization, along with a 7-megapixel front shooter. And since one of the iPad Pro’s chief advantages over the regular iPad is compatibility with the Apple Pencil, there’s also a redesigned Retina display that achieves smoother scrolling and drawing with the pencil thanks to 20-millisecond latency.If you’re editing video footage with your iPad Pro, the expanded screen real estate, better Pencil reaction times and A10X chip will likely make for a smoother experience. And if you’re editing video outside or in other challenging light conditions, you’ll appreciate that the display can automatically adjust its white balance to compensate. While that feature is also available in the previous generation, it’s another reason to chose the iPad Pro over the iPad.The main reason not to spring for the iPad Pro is, of course, its astronomical price, and that’s no less true with Monday’s update. If you’re a current 9.7-inch iPad Pro owner, you’ll need to replace your keyboard if you upgrade to the 10.5-inch model. Apple is offering a new $159 full-size Smart Keyboard that also doubles as a cover to fit the 10.5-inch iPad Pro.Add the keyboard and pencil ($99) to the $649 asking price for the 64GB Wi-Fi-only 10.5-inch iPad Pro, and you start to enter ultrabook territory, which means that even with a larger size, the base-model iPad Pro will have limited appeal among cost-conscious professionals. The refreshed 12.9-inch model, which gets the same internal improvements as its little cousin, starts at $799 for a 64GB Wi-Fi-only version. Both models can be ordered starting Monday with a cellular antenna for an additional $130. iOS 11 will bring additional capabilities to the iPad Pro when it rolls out this fall, including new multi-tasking features like drag and drop and an easier-to-use app picker menu. Apple Register Now » Add to Queue News reporter Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goalscenter_img Next Article This story originally appeared on PCMag iPad Pro Gets a Bigger Screen, But Comes at a High Price Tom Brant Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. This fall, iOS 11 will also bring additional multi-tasking capabilities, like drag and drop.last_img read more

Should You Launch an ICO to Raise Money for Your Startup

first_img Guest Writer Learn how to successfully navigate family business dynamics and build businesses that excel. In the past few months, you’ve likely heard about initial coin offering (ICO) fundraising, as some startups have experienced a significant amount of funding this way. Could ICOs replace traditional venture capital?On the surface, ICOs appear to be the new, successful startup journey alternative. However, before making any hasty decisions, it is imperative that you understand how these two very different types of funding compare.Related: Basic Blockchain Lingo Every Entrepreneur Needs to KnowICOs have seen immense growth, but there are challenges.There’s been a significant amount of media coverage in relation to ICOs, especially as the blockchain and cryptocurrency industry evolves. However, taking a closer look, it appears that there are some critical gaps in the available information, which for many is misleading.Of course, there are advantages to this model, including more rapid funding and fewer regulations — which may actually be a double-edged sword. Unlike the traditional model, which requires startups to first build a company, generate revenue, and then get funding from angel investors (before landing a venture capitalist), ICOs provide somewhat of a shortcut.The growth of ICOs alone is enough to turn heads. In June of this year, ICOs surpassed $550 million in funding, which was more than what was raised through venture capital fundraising. However, these benefits are not enough to convince many partners and investors.Being an open, unregulated system, anything can happen, and when you’re dealing with millions of dollars, “anything” isn’t exactly what you want to hear. In fact, one of the primary concerns for investors is the ambiguity of utility tokens, resulting in varying rights. There are also a number of significant risks involved, including taxable proceeds.Related: 3 Things You Need to Know Before Starting Your Own ICOICOs simply are not ready to take over traditional venture capital. Here’s why.Although many support ICOs and blockchain technology overall, it is the general consensus that the technology itself is still immature, leading to many risk factors. In some countries, such as China, ICOs have been banned due to a lack of regulation, as well as a high rate of fraudulent and illegal activity.If you are considering the ICO market to fund your startup, please consider the following in relation to traditional venture capital.Poor liquidity. Although companies are raising real capital, without enough liquidity, the participation from buyers quickly outweighs the supports of market buyers. Strict regulations and the use of multiple currencies also contribute to poor liquidity.Quality control and increased risk of scams. One review, published by The Wall Street Journal, found that after analyzing 1,450 ICOs, 20 percent contained major red flags. This included plagiarized documents, fake executive teams and guaranteed returns.Higher failure rate. As of February 2018, 46 percent of the previous year’s ICOs had already failed — despite the fact that they had raised more than $104 million. This is resulting in what’s referred to as a “digital graveyard,” as many of these ICOs appear to have been doomed from the start.At the end of the day, the majority of ICO-funded startups are poorly managed and lack the required cash flow. Since the cash raised by an ICO doesn’t technically have any legal leverage, as they are not currently regulated, this option is risky for investors, as well as your reputation.Related: Want to Invest in an ICO in 2018? Here’s All You Need to Know.Token sales and the phenomenon surrounding ICOs certainly has potential, but it’s still in its infancy. It’s the new “Wild West,” and until some of the major kinks are worked out, venture capital is still largely the most promising route, as you will attract loyal investors while building valuable connections.Regardless, this is an industry that should be watched closely, as many industry leaders, including Bill Gates and John Donahoe, support the evolution of digital currency. Based on your current business model and business plan, are you unsure which option is best? 4 min read July 18, 2018 Register Now » Image credit: Peshkova | Getty Images Rahul Varshneya Add to Queue As of February 2018, 46 percent of the previous year’s ICOs had already failed — despite the fact that they had raised more than $104 million. –shares Opinions expressed by Entrepreneur contributors are their own. Next Article Should You Launch an ICO to Raise Money for Your Startup? Free Webinar | July 31: Secrets to Running a Successful Family Business Technology Co-founder at Arkenealast_img read more

Bill Gates Says These Tech Innovations Will Change the World

first_img Register Now » February 28, 2019 The billionaire philanthropist weighed in on the scientific advances that he believes will make an impact in 2019 and beyond Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Bill Gates has made his fortune, and has given much of it away, thinking about the endeavors that will make our the world a healthier, connected and equitable place. Recently, the MIT Technology Review asked the Gates Foundation and Microsoft co-founder to share the inventions and technologies that he believes will effect real change this year and beyond.Some of the advances he offered up include projects such as Dactyl, which teaches robots how to develop fine motor skills like flipping a block in its hand, and work being done to develop machines that could pull carbon dioxide from the air to lessen the effects of climate change.Given his interest in improving conditions around the world, it’s unsurprising that most of the innovations on Gates’s list focus on wellness.Related: Bill Gates Made These 15 Predictions Back in 1999 — and It’s Scary How Accurate He WasSome of these include green toilets that can get rid of waste and treat water at the same time, plant-based meat alternatives that are developed in the lab, customized cancer vaccines tailored to an individual patient’s needs and a capsule with a mini microscope attached to it that would allow physicians to check kids and infants for gut issues without having to use anesthesia.Looking even further ahead to the future, Gates shared what we wanted to see on his potential list 20 years from now.“I would hope to see technologies that center almost entirely on well-being. I think the brilliant minds of the future will focus on more metaphysical questions: How do we make people happier? How do we create meaningful connections? How do we help everyone live a fulfilling life?” Gates wrote. “I would love to see these questions shape the 2039 list, because it would mean that we’ve successfully fought back disease (and dealt with climate change). I can’t imagine a greater sign of progress than that.” Bill Gates Says These Tech Innovations Will Change the World Bill Gates –shares Next Article center_img Staff Writer. Covers leadership, media, technology and culture. 2 min read Image credit: Thierry Monasse | Getty Images Nina Zipkin Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Add to Queue Entrepreneur Stafflast_img read more

Updates Make Uber More Accessible to the Deaf Start Up Your Day

first_imgStart Up Your Day April 20, 2016 Image credit: Shutterstock | Enhanced by Entrepreneur –shares 2019 Entrepreneur 360 List Entrepreneur Staff Add to Queue Entrepreneur Staffcenter_img 1 min read Updates Make Uber More Accessible to the Deaf – Start Up Your Day Roundup Next Article Looking for the latest headlines in small business, innovation and tech? Our Start Up Your Day recaps are posted every morning to keep you current. Accessible. And update makes Uber more accessible to deaf drivers and passengers.  Super users. Facebook might start paying some users, says Fortune. Slipping. Yahoo’s sale can’t come quickly enough. This past quarter it posted a double digit loss. One of a kind. Each city has it’s own microbe signature, according to a new study.   About the other night. Customer whose midnight McDonald’s story went viral has a confession: He made it up. Good bit in the eighties. The Commodore 64 is having a comeback — with some important updates.  The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apply Now »last_img read more

Study evaluates liability effects of hospital communicationandresolution programs

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 3 2018To be more transparent and to promote communication with patients after medical injuries, many hospitals have implemented a new approach called the communication-and-resolution program (CRP). Through these programs, hospitals openly communicate with patients after adverse events, investigating specifics, providing explanations, and, when necessary, taking responsibility and proactively offering compensation. Medical centers that have adopted this program believe it will help to improve patient safety and that it is the hospital’s ethical obligation to disclose medical errors. However, some medical centers are wary that willingly admitting errors could result in increased liability costs. Continuing uncertainty about this issue has continued to be a barrier to the widespread adoption of this program.A team of researchers at Brigham and Women’s Hospital, Baystate Medical Center (BMC), Beth Israel Deaconess Medical Center (BIDMC), Stanford Health Care, and Ariadne Labs, evaluated the liability effects of these communication-and-resolution programs at four Massachusetts hospitals. Their results, published today in a special, “patient safety” edition of Health Affairs, found that these programs were associated with improved trends in the rate of new claims and legal defense costs at some of the sites. And they found that the approach did not expand liability risk at any of the sites. The program allowed these organizations to fulfill their ethical obligations to disclose adverse events and promote patient safety without encountering negative liability consequences.”The CRP approach allows hospitals to ‘do the right thing’ — be honest about errors, apologize, and compensate patients who are injured by negligence – without adverse financial consequences,” said Allen Kachalia, MD, JD, chief quality officer at Brigham and Women’s Hospital and first author on the paper.A communication-and-resolution program known as CARe (Communication, Apology, and Resolution) was implemented at BMC and BIDMC, and at two of each center’s community hospitals (Baystate Franklin Medical Center, Baystate Mary Lane Hospital, Beth Israel Deaconess Hospital-Milton, and Beth Israel Deaconess Hospital-Needham). The team examined the effect of CARe’s malpractice claims volume, compensation and legal defense costs, and the time it took to find resolutions. They compared trends in the six years before CARe and then a few years after implementation at each institution. They calculated several quarterly rates for each hospital: new claims, new claims receiving compensation, compensation cost, defense cost, total liability cost, and average compensation cost. A claim was defined as any written request for patient compensation that was brought to the liability insurer, whether initiated by the patient, family, or hospital. This is the first study of its kind that involves two centers in one state and includes comparison groups.Related StoriesBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryRaw meat can act as reservoir for bacteria associated with hospital infectionsIt is okay for women with lupus to get pregnant with proper care, says new studyAfter CARe implementation, the team found there was a significant decrease in the rate of new claims at the implementing community hospitals and academic medical centers, a change that was not seen at hospitals that did not implement CARe. Both academic medical centers experienced a significant decrease for defense costs after CARe implementation. Additionally, there were no significant changes in total liability costs observed nor in the average compensation amount per paid claim at any of the hospitals.”Our hope is that with these findings, more hospitals will have greater confidence that communicating openly with patients around errors and injury is not likely to create greater liability risk,” said Kachalia.In its special edition, Health Affairs also published papers by David Bates, MD, and Gordon Schiff, MD, on patient safety concerns:Bates’ paper, “Two Decades Since To Err Is Human: An Assessment Of Progress And Emerging Priorities In Patient Safety,” reviews the Institute of Medicine’s “To Err Is Human” report, which initially brought the problem of patient safety into the public eye 20 years ago. Some of the areas the paper reviews include the evolving identification of patient safety issues, the development and adaptation of effective interventions for hospital-acquired infections, and the emergence of new safety risk areas, including diagnostic error and technology-related concerns.In Schiff’s paper, entitled “A Prescription for Enhancing Electronic Prescribing Safety,” he and a team of clinicians, communications safety, and health IT experts outlined six steps and areas of improvement to a safer and easier electronic prescribing system that could lead to fewer errors and better cost-effectiveness. Source:https://www.brighamandwomens.org/last_img read more

New study could improve methods for detecting congenital heart disease

first_imgReviewed by James Ives, M.Psych. (Editor)Apr 4 2019A new study by biomedical engineering researchers at the University of Arkansas could significantly improve methods for detecting and diagnosing congenital heart disease in infants and small children.The researchers, collaborating with cardiologists at Arkansas Children’s Hospital in Little Rock, tested a new ultrasound technology called vector flow imaging for the first time on pediatric patients to create detailed images of the internal structure and blood flow of the babies’ hearts. The images can be still or moving, and can be taken from any angle.”Vector flow imaging technology is not yet possible in adults, but we have demonstrated that it is feasible in pediatric patients,” said Morten Jensen, associate professor of biomedical engineering at the U of A. “Our group demonstrated that this commercially available technology can be used as a bedside imaging method, providing advanced detail of blood flow patterns within cardiac chambers, across valves and in the great arteries.”Jensen performed the study with a multidisciplinary team, including Dr. Hanna Jensen, clinical assistant professor of biomedical engineering at the U of A; Dr. Thomas Collins, clinical associate professor of pediatric cardiology at Stanford University School of Medicine; and researchers at University of Arkansas for Medical Sciences (UAMS) and Cincinnati Children’s Hospital Medical Center. Their findings were published in Progress in Pediatric Cardiology.Roughly 1 percent of all babies are born with some type of congenital heart defect. Fortunately, the majority of these defects will never have any significant impact as the child grows into adulthood and old age. Pediatric cardiologists detect and diagnose congenital heart disease through multiple processes, including echocardiography. This imaging method is based on ultrasound and assesses the overall health of the heart, including valves and muscle contraction.Related StoriesBioTek introduces new wide FOV camera for Cytation 5 Cell Imaging Multi-Mode ReaderMathematical model helps quantify metastatic cell behaviorQueen Mary University of London’s BCI boosts radionuclide imaging capabilities with MILabs VECTor technologyAlthough ultrasound provides essential information about cardiac valve function in babies and small children, it has critical limitations. It cannot accurately obtain details of blood flow within the heart. This is due primarily to the inability to align the ultrasound beam with blood-flow direction.Using a BK5000 Ultrasound machine with built-in vector flow imaging, the researchers performed successful tests on two pigs, one with normal cardiac anatomy and one with congenital heart disease due to a narrow pulmonary valve and a hole within the heart. The researchers then compared the vector flow images to direct examination of the pigs’ hearts.The researchers subsequently used the imaging system to take cardiac images of two three-month-old babies, one with a healthy, structurally normal heart and one with congenital heart disease because of an abnormally narrow aorta. With both patients, the technology-enabled total transthoracic imaging of tissue and blood flow at a depth of 6.5 centimeters. Abnormal flow and detailed cardiac anomalies were clearly observed in the patient with congenital heart disease.All procedures, both animal and human, were performed at Arkansas Children’s Hospital with assistance from Dr. Elijah Bolin, pediatric cardiologist at UAMS.”We are still getting used to having this great, new information readily available, and we’re excited about the future in both research and direct clinical advancements,” Bolin said.”This technology will increase our ability to provide the best possible bedside diagnosis and greatly enhances our understanding of what is happening in hearts with complex abnormalities,” Stanford’s Collins said.The researchers will perform additional studies to further quantify images using this recently developed technology. Source:http://www.uark.edu/last_img read more

Researchers succeed in humanization of mouse antibodies targeting human herpesvirus 6B

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Apr 26 2019A research group led by Professor Yasuko Mori (Division of Clinical Virology, Center for Infectious Diseases, Kobe University) have succeeded in humanization of mouse antibodies that can neutralize the infection caused by human herpesvirus 6B (HHV-6B). Infection by HHV-6B in infants can lead to complications such as encephalitis (brain inflammation) but an effective way to control the infection has not yet been found.Professor Mori’s research team created “humanized” antibodies based on the mouse (murine) antibodies for HHV-6B. The findings were published on March 6 in the online edition of theJournal of Virology, and have also been introduced in the HHV-6 Foundation Newsletter.Almost every child between the ages of six and eighteen months will become infected with HHV-6B. The initial infection causes sudden-onset fever and rash. The condition has a favorable prognosis, but roughly 150 cases a year result in encephalitis and around half of these patients are left with neurological complications. HHV-6B remains latent in our bodies after initial infection, and can reactivate when our immune system defenses are low. This can be particularly bad for patients who have received stem cell transplants, who can experience frequent and life-threatening encephalitis after transplantation.Professor Mori’s team had already identified the protein complex gH/gL/gQ1/gQ2 as an essential factor for HHV-6B infection, and the human cellular receptor CD134 (OX40) that expresses on stimulated T-cells, the targets of infection. They showed in previous studies that the interaction between this protein complex and receptor is the key to infection (Figure 1). By creating monoclonal antibodies from mice, they showed that antibodies which block the activity of the gH/gL/gQ1/gQ2 complex can be used to regulate the HHV-6B infection (figure 1). The team’s next goal is to develop clinically applicable treatment that can tackle the HHV-6B gH/gL/gQ1/gQ2 complex.Related StoriesTreating women with thyroid antibodies with Levothyroxine do not increase live birth ratePremature babies also have protective anti-viral antibodiesScientists discover rare autoimmune disease triggered by testicular cancerHowever, antibodies from mice are targeted by the human immune system and destroyed when they enter our bodies, so further alterations are necessary to suppress the immune reaction in our bodies before this can be used in clinical settings. Using gene-altering technology, the team tested the humanization of mouse antibodies: they created a chimeric antibody by replacing the mouse antibodies with human antibodies in the constant domain, only leaving the parts in the variable domain that directly act against HHV-6B.In this study the team altered two types of mouse IgG antibodies to target gH and gQ1 in the HHV-6B gH/gL/gQ1/gQ2 complex. First they analyzed the DNA sequence of the mouse antibodies, and made a chimeric human-mouse gene (figure 2). They purified the chimeric antibodies produced by introducing this gene to cell cultures, and confirmed that the antibodies had maintained their effectiveness against the HHV-6B gH/gL/gQ1/gQ2 complex. By carrying out further quantitative analysis they verified that the chimera antibodies were able to block the infection of HHV-6B with the same effectiveness as mouse antibodies.This research successfully created artificial antibodies which are both effective against HHV-6B and trigger a lower response from the human immune system. These antibodies still contain parts that originate from mice, so the next step is to replace these parts with human antibodies to create antibodies that are suitable for clinical use. HHV-6B only infects humans, meaning there is no animal model for infection, and it is hard to evaluate the effectiveness of these antibodies within a living organism. In the future if animal models can be available to test this, we hope that the results can help to create antibody-based treatments for HHV-6B infection. Source:http://www.kobe-u.ac.jp/research_at_kobe_en/NEWS/news/2019_04_26_01.htmllast_img read more

Lenovo posts firstquarter profit as recovery continues

first_img Citation: Lenovo posts first-quarter profit as recovery continues (2018, August 16) retrieved 18 July 2019 from https://phys.org/news/2018-08-lenovo-first-quarter-profit-recovery.html Chinese technology giant Lenovo Thursday recorded a sharp rise in first quarter net profit as the company’s turnaround gathered pace. Lenovo posts $189 mn full-year loss on one-time write-off The PC maker posted a $77 million net profit in the quarter to June 30—up from a $72 million loss in the same period last year.”The Group remains confident in its core PC business, and aims to grow … without compromising on profitability,” chairman Yang Yuanqing said in a statement.Analyst Jackson Wong said competition between PC makers “is not as fierce as it is in the mobile sector”, while Lenovo’s focus on hardware has also contributed to the positive results.Lenovo also reported a 19 percent rise in revenue to $11.91 billion—its second consecutive quarter of double-digit revenue growth.The tech giant is turning its fortunes around following a $189 million net loss for the full fiscal year, dragged down by a $400 million non-cash write-off charge from deferred income tax assets.The company’s shares rose up to six percent to HK$4.72 mid-morning after the results were released. © 2018 AFP Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Shipbuilders replace stealthy US destroyers 15ton turbine

first_img Explore further Shipbuilder Bath Iron Works has replaced one of the massive turbines on the future USS Michael Monsoor, and the stealthy destroyer is scheduled to depart for San Diego in November. In this Dec. 4, 2017 file photo, the future USS Michael Monsoor leaves Bath Iron Works for sea trials in Bath, Maine. The shipbuilder has replaced one of the massive turbines on the stealthy destroyer. It is scheduled to depart for San Diego in November. (AP Photo/Robert F. Bukaty, File) Navy’s 2nd stealthy destroyer heads out to sea for 1st time (Update) © 2018 The Associated Press. All rights reserved.center_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Shipbuilders replace stealthy US destroyer’s 15-ton turbine (2018, August 31) retrieved 17 July 2019 from https://phys.org/news/2018-08-shipbuilders-stealthy-destroyer-ton-turbine.html The delicate operation involved lifting and maneuvering the 15-ton Rolls Royce marine turbine out of the ship, and workers had to build a rail system to assist in the removal and installation of the replacement turbine in August, officials said.”The number of twists and turns it had to go through represented a pretty interesting engineering evolution,” said shipyard President Dirk Lesko.Shipbuilders noticed an unusual vibration during sea trials and discovered afterward that a foreign object had damaged some of the blades the turbine was installed, Lesko said. Although the turbine still works, the Navy decided to replace rather than repair the unit.The Zumwalt-class destroyers use two main turbines similar to ones used on Boeing 777 jetliners to produce electricity that powers the ship and its sophisticated systems. Combined with auxiliary turbines, the ship produces 78 megawatts of power, enough for a small- to medium-size city.The Zumwalt and Monsoor are the first and second in a class of three of the stealthy destroyers. The third, the Lyndon B. Johnson, remains under construction.The Monsoor repairs presented an inconvenience because the Navy crew is already aboard the ship, and the repairs interrupted some of their training, Lesko said.”We tried to work around them in a way that would be minimally impactful,” he said. “We were both satisfied with how that turned out.”The destroyer, named for a Navy SEAL who threw himself on a grenade to save comrades, is due to be commissioned in January in Coronado, California.The ships with an unusual, stealthy shape are the largest and costliest destroyers built for the Navy, weighing in at 15,000 tons.They feature an unconventional wave-piercing hull and a sleek deckhouse that hides radar and other sensors inside. Heavy automation allowed the Navy to reduce the crew size by half, compared with the other destroyers in the fleet.last_img read more

Apple profit stable as service gains offset iPhone slump

first_img © 2019 AFP Profit in the final quarter of last year was $20 billion—a dip of less than one percent—on revenue of $84.3 billion, even as money from iPhone sales was down 15 percent from the same period in 2017.The full extent of the slump in iPhone sales was not clear because Apple for the first time stopped reporting unit sales for its iconic smartphones.Overall revenue for Apple dipped nearly five percent from a year ago, in line with the lowered guidance earlier this month that stunned the market and hammered shares of the iPhone maker.”While it was disappointing to miss our revenue guidance, we manage Apple for the long term, and this quarter’s results demonstrate that the underlying strength of our business runs deep and wide,” chief executive Tim Cook said in the earnings release.The update for Apple’s first fiscal quarter to December 29 was greeted with relief on Wall Street, as shares rallied 5.75 percent in after-hours trade.Pressure to diversifyApple had been under pressure to show it can weather the slump in the global smartphone market and diversify its revenue base, and the latest results appeared to satisfy the market.Services revenue reached an all-time high of $10.9 billion, up 19 percent over the prior year. Apple also boosted sales of wearables and accessories by 33 percent from last year.Cook has long emphasized the potential of that side of Apple’s business.”Our active installed base of devices reached an all-time high of 1.4 billion in the first quarter, growing in each of our geographic segments,” Cook said.”It’s driving our Services business to new records thanks to our large and fast-growing ecosystem.”An Apple streaming music service launched in mid-2015 now boasts more than 50 million subscribers. Citation: Apple profit stable as service gains offset iPhone slump (2019, January 30) retrieved 17 July 2019 from https://phys.org/news/2019-01-apple-profit-stable-gains-offset.html Apple said revenue from iPhone sales dropped by 15 percent from a year ago but did not offer details on unit sales Apple said Tuesday that profits held steady in the most recent quarter, with revenue growth in music, movies, apps and other services offsetting slumping iPhone sales, sparking a rally in shares of the California tech giant. “We will participate in the original content world,” Cook said while discussing Apple’s plans for video content.”We have signed a multi-year partnership with Oprah,” he said, adding that Apple has hired “some great people” whom he is confident in.Losing steam?Apple took a hit in the “Greater China” region, where revenue plunged almost 27 percent, which had been expected following the company’s latest revenue warning.While Apple appeared to avoid the worst with its latest results, the long-term outlook is less certain, some analysts say.”While Apple is still a money-making machine, today’s uncharacteristic revenue decline symbolizes a company that is starting to run out of steam,” said Neil Saunders of the research firm GlobalData Retail.”In our view, this is something to be corrected, not least because Apple is a costly company to run and it relies on strong revenue growth to drive up the bottom line.”Cook contended weak economic conditions in China hurt iPhone sales, but said Apple had record services revenue there despite game apps facing difficulties getting approved by regulators.Saunders said the problems with iPhone sales and China pose significant threats to Apple’s future.”Apple is fortunate in having a strong base of fans and many consumers who are bought into its ecosystem of services,” Saunders said.”But without device innovation, even this will be insufficient to maintain iPhone market share in the face of rising competition.” Apple shares slide after disappointing holiday outlook Explore further And the California-based company looks to build momentum for its Apple TV service, with deals to have it installed on television models coming out this year.During the earnings call, Cook confirmed that Apple plans to produce its own shows in a move that could challenge streaming television giants Netflix and Amazon Prime, which have invested heavily in original content. Apple met its recently lowered guidance for the most recent quarter, sparking a rally in after-hours trade This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more