TV and Movies Everyone in kings landing. #GameofThrones pic.twitter.com/pnf4uB8Ua4— Danish Khurshid (@ShahDanish_) May 13, 2019 The Mad Queen? HBO It’s been an up and down season for Game of Thrones. A dragon was killed in ways that frustrated and annoyed everyone, everyone got extremely angry when Jon Snow didn’t pet Ghost and then the internet found a coffee cup on set and went buck wild.This episode was all about the insane carnage.OK, goes without saying but…It started early with the burning of Varys. And the burning just didn’t stop.The question going in was simple: Was Dany about to become the Mad Queen, or was it all just a big swerve?Yeah, they answered that pretty definitively. Daenerys Targaryen basically set all of King’s Landing on fire. The Bells rang out for surrender but Dany wasn’t trying to hear that noise. Me, The entire episode #GameOfThrones pic.twitter.com/Ss3l6yx4cT— 𝑨𝒓𝒊 𝐒𝐭𝐚𝐫𝐤 (@solangev_a) May 13, 2019 Bran chilling in Winterfell while Daenerys kills everyone: #GameofThrones pic.twitter.com/KQKBLoAGL1— MWV Highlights (@MWV_Highlights) May 13, 2019 Waiting all these years for main character deaths and we see stone crushing them. #GameofThrones pic.twitter.com/Vh76HcdKBG— Shay (@shayycs) May 13, 2019 6:20 I’ve been working very very hard not to do any spoilers but I will say this: I look forward to reading the book and seeing how #GameofThrones really ended.Because this isn’t it.— Steve Spohn (@stevenspohn) May 13, 2019 Drogon after that episode #GameofThrones pic.twitter.com/hUQtS8Btya— church (@COFFINBORNEGOD) May 13, 2019 See all the Game of Thrones season 8 photos Jon Snow halfway through the episode#GameofThrones pic.twitter.com/eSVnbqEADW— T (@I_Gas247) May 13, 2019 All the haters should just go to sleep. That episode was phenomenal. I’m sick of people’s negativity. Get outta here. #GameOfThrones pic.twitter.com/XBDqjDBJWi— Seth Nelson (@RealSethNelson) May 13, 2019 Now playing: Watch this: Soldiers: The bells are ringing! Danny: Are they though? #GameofThrones pic.twitter.com/8ieNiW10BM— Ron Snow (@RonMorrisse) May 13, 2019 It’s a nice little throwback to this: #gameofthrones me: dany won’t murder all these innocent people they rang the bells we’re all good!!!dany: (: dracarys me: pic.twitter.com/OVGjw8wT8S— madz🦋✨💫 (@maddyackerburg) May 13, 2019 Dany after this episode#GameofThrones pic.twitter.com/3u935UflEp— Jonas Ryan (@jonasryan_) May 13, 2019 Us spending the last 10 years of our lives emotionally attached to a TV show only for the writers to just give us the worst ending possible. #GameofThrones pic.twitter.com/CNcmVm4H0S— Caleb (@CalebKesler) May 13, 2019 Tags This was from a Season 4 promo. We all thought it was snow.. little did we know it was ash. #GameOfThrones pic.twitter.com/ieVUaaQPV8— Chris Brown (@chriscbrown) May 13, 2019 36 #GameofThrones #GoTAll the parents who named their daughter khaleesi or dany: pic.twitter.com/qf9EwTp6Ha— Ali (@Ali_Givenchy) May 13, 2019 The writers destroying the entire show in the final season #GameOfThrones pic.twitter.com/vXtJgAyDTs— Valentina ☕️ (@ValsCappuccino) May 13, 2019 Comments Share your voice Jon, Sansa and Tyrion plotting to kill Danny next week: #GameOfThrones pic.twitter.com/lCBVvJ9EDF— Ebony Barzilay (@o_hon_ey) May 13, 2019 187 Photos That game of thrones episode was wild— timthetatman (@timthetatman) May 13, 2019 Thoughts? Well, Mad Queen Dany is bad and everyone should feel bad. Very disappointed we spent a decade watching a really great female leader emerge, with a very cool and consistent “break the wheel” message only to have it completely turned around at the last, crucial minute. Not sure it entirely made sense, but I sure had a lot of fun watching it all unfold.I do get the sense that a backlash to the backlash is imminent. I can’t believe I had to watch that bullshit of an episode with my own two eyes #GameOfThrones pic.twitter.com/ue4hf0J18t— jedi in training (@totallyxtaylor) May 13, 2019 “I probably should’ve told someone the dragon lady was crazy.” #GameofThrones pic.twitter.com/YK3d6j5N27— Diane N. Sevenay (@Diane_7A) May 13, 2019 The carnage was insane and dramatic and very Game of Thrones, but did it make sense? Hmmmmm….. Even if Dany was pissed and wanted to destroy Cersei why wouldn’t she just go straight to the Red Keep instead of zig zagging destruction through the city IT MAKES NO SENSE #GameofThrones— Jenna Guillaume (@JennaGuillaume) May 13, 2019 missandei, in heaven looking at kings landing. #GameofThrones pic.twitter.com/mjBFEdbM0z— Justin Jay, Conclave Liasion 💚💙💛 (@_DubzyWubzy_) May 13, 2019 Game of Thrones season 8 episode 5: Everybody hurts Yep, Dany basically burned everything down and killed thousands of people. Not sure if King’s Landing as we knew it even exists any more. Next week is going to be extremely interesting. Meanwhile… So you all just going to act like you didn’t see this coming? Danys been whack from the start and you’re all fools if you didn’t think this was going to happen #GameofThrones pic.twitter.com/GMQdOKXPWf— clara maxwell (@claramaxwell99) May 13, 2019 Me trynna figure out did I really watch all them seasons for this #gameofthrones pic.twitter.com/XpZCTA0TuS— tingz (@_Inez__) May 13, 2019 HBO & the 3 fans that are actually enjoying this season of #GoT pic.twitter.com/VgxQbvNdcQ— VS (@valon_sej) May 13, 2019 everyone say THANK YOU LENA HEADEY for her phenomenal perfomance as cersei lannister, one of my favorites ever.power is power. you will be missed.#GameOfThrones pic.twitter.com/ycwauGBjFh— lucca (@davnerys) May 13, 2019 meanwhile tormund and ghost #GameOfThrones pic.twitter.com/x9WQH2tLDH— 💌 (@hugehoops) May 13, 2019 Game of Thrones
A drug that stops the spread of cancer has been developed, with scientists identifying the cells responsible for initiating and promoting metastasis. While the drug has only been tested on mouse models, researchers are hopeful the discovery will have widespread applications for future cancer treatments.Metastasis the process through which cancer spreads from one part of the body to another. It is one of the aspects of the disease that makes it so deadly – indeed, it is the reason behind 90% of human cancer deaths. The process by which cancer spreads is extremely complex. The cells that trigger metastasis are not known, so the development of therapies to prevent it is challenging.However, a team of researchers led by Gloria Pascual of the Institute for Research in Biomedicine (IRB Barcelona) has now found these cells, and shown how they can be used to stop the spread of cancer.In a study published in the journal Nature, the team found a specific protein – CD36 – in the membranes of tumour cells that are responsible for taking up fatty acids (a receptor). The team discovered CD36+ cells in samples of human oral carcinoma (oral cancer).When CD36 was absent from the tumours, they did not develop metastasis. When it was added, the tumours became metastatic.Researchers then looked at CD36 in mouse models of oral, melanoma and breast cancer. After treating them with antibodies to block the receptor, metastasis was either significantly reduced or totally eliminated. Furthermore, metastases already present shrunk or disappeared. Where matastases was already established, the treatment removed it in 20% of the cases, and reduced it in between 80-90% of the remainder. There were no significant side-effects observed.Cancer metastasis dependent on fat? Because CD36 is responsible for the uptake of fatty acids, the researchers looked at what role fat intake has on the spread of cancer. To do this, they provided one group of mice with a high-fat diet and inoculated them with oral cancer. In the control group, 30% went on to develop metastasis, compared to 80% of the high-fat group. This indicates a high-fat diet increases the risk of metastasis.Aznar Benitah said: In mice inoculated with human tumour cells, there appears to be a direct link between fat intake and an increase in metastatic potential through CD36. More studies are needed to unravel this intriguing relationship between diet and metastasis, above all because industrialised countries are registering an alarming increase in the consumption of saturated fats and sugar.Fat is necessary for the function of the body, but uncontrolled intake can have an effect on health, as already shown for some tumours such as colon cancer, and in metastasis, as we demonstrate here.Further analysis showed metastasis is also dependent on CD36 in ovarian, bladder and lung cancer. Findings indicate there could be a general mechanism that underlies metastasis – and treatments that block CD36 could be key to stop the spread of cancer.Although we have not yet tested this in all tumour types, we can state that CD36 is a general marker of metastatic cells, the first marker I know of that is generally specific to metastasis, said Salvador Aznar Benitah, head of the Stem Cell and Cancer Lab at IRB Barcelona.We expect this study to have a big impact on the scientific community and to further advances in metastasis research, and we hope to be able to validate the potential of CD36 as an anti-metastasis treatment. Things like this dont happen every day.The team is now working with researchers in the UK to develop antibody-based treatments that work against CD36 for a range of cancers. If successful, they believe a new drug could be available in five to 10 years. IBTimes VideoRelated VideosMore videos Play VideoPlayMute0:00/0:00Loaded: 0%0:00Progress: 0%Stream TypeLIVE0:00?Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedSubtitlessubtitles settings, opens subtitles settings dialogsubtitles off, selectedAudio TrackFullscreenThis is a modal window.The media could not be loaded, either because the server or network failed or because the format is not supported.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window. COPY LINKAD Loading … Drug that stops the spread of cancer has been developed Close
Donald Trump. File PhotoUS president Donald Trump said military intervention in Venezuela was “an option” as Western nations boost pressure on socialist leader Nicolas Maduro to step down, while the troubled OPEC nation’s ally Russia warned against “destructive meddling.”The United States, Canada and several Latin American countries have disavowed Maduro over his disputed re-election last year and recognized self-proclaimed president Juan Guaido as the country’s rightful leader.Trump said US military intervention was under consideration in an interview with CBS aired on Sunday.”Certainly, it’s something that’s on the – it’s an option,” Trump said, adding that Maduro requested a meeting months ago.”I’ve turned it down because we’re very far along in the process,” he said in a “Face the Nation” interview. “So, I think the process is playing out.”The Trump administration last week issued crippling sanctions on Venezuelan state-owned oil firm PDVSA, a key source of revenue for the country, which is experiencing medicine shortages and malnutrition.Maduro, who has overseen an economic collapse and the exodus of millions of Venezuelans, maintains the backing of Russia, China and Turkey, and the critical support of the military.Russia, a major creditor to Venezuela in recent years, urged restraint.”The international community’s goal should be to help (Venezuela), without destructive meddling from beyond its borders,” Alexander Shchetinin, head of the Latin America department at Russia’s Foreign Ministry, told Interfax.France and Austria said they would recognize Guaido if Maduro did not respond to the European Union’s call for a free and fair presidential election by Sunday night.”We don’t accept ultimatums from anyone,” Maduro said in a defiant interview with Spanish television channel Antena 3 carried out last week and broadcast on Sunday.”I refuse to call for elections now – there will be elections in 2024. We don’t care what Europe says.”Emboldened OppositionThe 35-year-old Guaido, head of the country’s National Assembly, has breathed new life into a previously fractured and weary opposition. Tens of thousands of people thronged the streets of various Venezuelan cities on Saturday to protest Maduro’s government.Guaido allies plan to take a large quantity of food and medicine donated by the United States, multilateral organizations and non-profit groups across the Colombian border into the Venezuelan state of Tachira this week, according to a person directly involved in the effort.The group has not yet determined which border point it will cross, said the person, who asked not to be identified because he is not authorized to speak publicly about the issue.It is unclear whether Maduro’s government, which denies the country is suffering a humanitarian crisis, will let any foreign aid through.The embattled president on Sunday promised peace for Venezuela without specifically responding to Trump.”In Venezuela, there will be peace, and we will guarantee this peace with the civil military union,” he told state television, in the company of khaki and black-clad soldiers who were earlier shown carrying guns and jumping from helicopters into the sea.Maduro has overseen several such military drills since Guaido declared himself president to display he has the backing of the military, and that Venezuela’s armed forces are ready to defend the country.Air Force General Francisco Yanez disavowed Maduro in a video this weekend, calling on members of the military to defect. But there were no signs the armed forces were turning against Maduro.Venezuela has as many as 2,000 generals, according to unofficial estimates, many of whom do not command troops and whose defection would not necessarily weaken the ruling socialists.The police have also fallen in line with Maduro.A special forces unit called FAES led home raids following unrest associated with opposition protests in January, killing as many as 10 people in a single operation in a hillside slum of Caracas.Venezuela’s ambassador to Iraq, Jonathan Velasco, became the latest official to recognize opposition leader Guaido this weekend.